N₁-(2-(dipropylamino)ethyl)-N₄-((S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-yl)terephthalamide hydrochloride

Base Information

• Chemical Name: N₁-(2-(dipropylamino)ethyl)-N₄-((S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-yl)terephthalamide hydrochloride
• CAS No.: 1346804-57-6
• Molecular Formula: C₃₄H₅₇N₅O₅*ClH
• Molecular Weight: 652.318

Synonyms:N₁-(2-(dipropylamino)ethyl)-N₄-((S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-yl)terephthalamide hydrochloride

Chemical Property of N₁-(2-(dipropylamino)ethyl)-N₄-((S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-yl)terephthalamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₁-(2-(dipropylamino)ethyl)-N₄-((S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-yl)terephthalamide hydrochloride

There total 6 articles about N₁-(2-(dipropylamino)ethyl)-N₄-((S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-yl)terephthalamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.5%

N1-((5S,8S,11S)-5,8-diisobutyl-3,13-dimethyl-4,7,10-trioxo-2-oxa-3,6,9-triazatetradecan-11-yl)-N4-(2-(dipropylamino)ethyl)terephthalamide (1346804-54-3) → N1-(2-(dipropylamino)ethyl)-N4-((S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-yl)terephthalamide hydrochloride (1346804-57-6)

Guidance literature:

N₁-((5S,8S,11S)-5,8-diisobutyl-3,13-dimethyl-4,7,10-trioxo-2-oxa-3,6,9-triazatetradecan-11-yl)-N₄-(2-(dipropylamino)ethyl)terephthalamide; With lithium aluminium tetrahydride; In diethyl ether; at -80 - 0 ℃; for 1.5h; Inert atmosphere;

With water; In diethyl ether; at 0 ℃; Inert atmosphere;

With hydrogenchloride; In diethyl ether; dichloromethane; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.07.037

Reference yield:

N,N-dipropylethanediamine (14165-22-1) → N1-(2-(dipropylamino)ethyl)-N4-((S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-yl)terephthalamide hydrochloride (1346804-57-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: trimethylaluminum / hexane; dichloromethane / 2 h / 0 - 5 °C / Inert atmosphere

1.2: 77 h / 0 °C / Reflux; Inert atmosphere

2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 1 h / 0 - 20 °C

3.1: benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide / dichloromethane / 1 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / diethyl ether / 1.5 h / -80 - 0 °C / Inert atmosphere

4.2: 0 °C / Inert atmosphere

4.3: Inert atmosphere

With lithium aluminium tetrahydride; lithium hydroxide monohydrate; trimethylaluminum; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water;

DOI:10.1016/j.ejmech.2011.07.037

Reference yield:

methyl 4-((2-(dipropylamino)ethyl)carbamoyl)benzoate (1346804-44-1) → N1-(2-(dipropylamino)ethyl)-N4-((S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-yl)terephthalamide hydrochloride (1346804-57-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 1 h / 0 - 20 °C

2.1: benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide / dichloromethane / 1 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / diethyl ether / 1.5 h / -80 - 0 °C / Inert atmosphere

3.2: 0 °C / Inert atmosphere

3.3: Inert atmosphere

With lithium aluminium tetrahydride; lithium hydroxide monohydrate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether; dichloromethane; water;

DOI:10.1016/j.ejmech.2011.07.037

upstream raw materials:

methyl 4-((2-(dipropylamino)ethyl)carbamoyl)benzoate

lithium 4-((2-(dipropylamino)ethyl)carbamoyl)benzoate

N₁-((5S,8S,11S)-5,8-diisobutyl-3,13-dimethyl-4,7,10-trioxo-2-oxa-3,6,9-triazatetradecan-11-yl)-N₄-(2-(dipropylamino)ethyl)terephthalamide

N,N-dipropylethanediamine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1346804-57-6 N₁-(2-(dipropylamino)ethyl)-N₄-((S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-yl)terephthalamide hydrochloride

Send

Send

Metric Ton KG G Pound L ML

Send

Send