((2S,6R)-6-(1-hydroxy-2-methylpropan-2-yl)tetrahydro-2H-pyran-2-yl)methyl 2,4,6-trimethylbenzenesulfonate

Base Information

Chemical Name:((2S,6R)-6-(1-hydroxy-2-methylpropan-2-yl)tetrahydro-2H-pyran-2-yl)methyl 2,4,6-trimethylbenzenesulfonate
CAS No.:1325653-80-2
Molecular Formula:C₁₉H₃₀O₅S
Molecular Weight:370.51
Hs Code.:

Synonyms:((2S,6R)-6-(1-hydroxy-2-methylpropan-2-yl)tetrahydro-2H-pyran-2-yl)methyl 2,4,6-trimethylbenzenesulfonate

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Chemical Property of ((2S,6R)-6-(1-hydroxy-2-methylpropan-2-yl)tetrahydro-2H-pyran-2-yl)methyl 2,4,6-trimethylbenzenesulfonate

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Technology Process of ((2S,6R)-6-(1-hydroxy-2-methylpropan-2-yl)tetrahydro-2H-pyran-2-yl)methyl 2,4,6-trimethylbenzenesulfonate

There total 5 articles about ((2S,6R)-6-(1-hydroxy-2-methylpropan-2-yl)tetrahydro-2H-pyran-2-yl)methyl 2,4,6-trimethylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1325653-42-6
((2S,6R)-6-(1-(benzyloxy)-2-methylpropan-2-yl)-5,6-dihydro-2H-pyran-2-yl)methyl 2,4,6-trimethylbenzenesulfonate

: 1325653-80-2
((2S,6R)-6-(1-hydroxy-2-methylpropan-2-yl)tetrahydro-2H-pyran-2-yl)methyl 2,4,6-trimethylbenzenesulfonate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; for 12h;
DOI:10.1021/ol201863b

Reference yield:

: 773-64-8
2-mesitylenesulphonyl chloride

: 1325653-80-2
((2S,6R)-6-(1-hydroxy-2-methylpropan-2-yl)tetrahydro-2H-pyran-2-yl)methyl 2,4,6-trimethylbenzenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine; dmap / dichloromethane / 72 h / 20 °C / Inert atmosphere

2: pyridine / tetrahydrofuran / 12 h / Inert atmosphere

3: trimethylsilyl trifluoromethanesulfonate / dichloromethane; benzene / 3 h / -78 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol / 12 h

With pyridine; dmap; trimethylsilyl trifluoromethanesulfonate; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1021/ol201863b

Reference yield:

: 1325653-68-6
C₁₃H₂₀O₂Si

: 1325653-80-2
((2S,6R)-6-(1-hydroxy-2-methylpropan-2-yl)tetrahydro-2H-pyran-2-yl)methyl 2,4,6-trimethylbenzenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine; dmap / dichloromethane / 72 h / 20 °C / Inert atmosphere

2: pyridine / tetrahydrofuran / 12 h / Inert atmosphere

3: trimethylsilyl trifluoromethanesulfonate / dichloromethane; benzene / 3 h / -78 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol / 12 h

With pyridine; dmap; trimethylsilyl trifluoromethanesulfonate; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1021/ol201863b