4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(3-methoxy-phenoxy)-4-pyrimidinyl]-benzenesulphonamide

Base Information

• Chemical Name: 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(3-methoxy-phenoxy)-4-pyrimidinyl]-benzenesulphonamide
• CAS No.: 150727-21-2
• Molecular Formula: C₂₃H₂₇N₃O₆S
• Molecular Weight: 473.55

Synonyms:4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(3-methoxy-phenoxy)-4-pyrimidinyl]-benzenesulphonamide

Chemical Property of 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(3-methoxy-phenoxy)-4-pyrimidinyl]-benzenesulphonamide

Chemical Property:

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Technology Process of 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(3-methoxy-phenoxy)-4-pyrimidinyl]-benzenesulphonamide

There total 1 articles about 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(3-methoxy-phenoxy)-4-pyrimidinyl]-benzenesulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium glycolate (25289-18-3,105938-46-3,2836-32-0) + 4-tert-butyl-N-[6-chloro-5-(o-methoxyphenoxy)-4-pyrimidinyl]-benzene sulfonamide (150727-24-5) → 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(3-methoxy-phenoxy)-4-pyrimidinyl]-benzenesulphonamide (150727-21-2)

Guidance literature:

With sodium; In ethylene glycol;

Reference yield:

5-Bromo-2-chloropyrimidine (32779-36-5) + 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(3-methoxy-phenoxy)-4-pyrimidinyl]-benzenesulphonamide (150727-21-2) → N-[6-[2-(5-bromo-pyrimidin-2-yloxy)-ethoxy]-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide

Guidance literature:

With sodium hydride; In N,N-dimethyl acetamide; at 20 ℃; for 48h;

DOI:10.1021/jm0102304

Reference yield:

2-chloro-5-(methylsulfanyl)pyrimidine (115581-36-7) + 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(3-methoxy-phenoxy)-4-pyrimidinyl]-benzenesulphonamide (150727-21-2) → 4-tert-butyl-N-{5-(2-methoxy-phenoxy)-6-[2-(5-methylsulfanyl-pyrimidin-2-yloxy)-ethoxy]-pyrimidin-4-yl}-benzenesulfonamide

Guidance literature:

With sodium hydride; In N,N-dimethyl acetamide; at 20 ℃; for 48h;

DOI:10.1021/jm0102304

upstream raw materials:

sodium glycolate

4-tert-butyl-N-[6-chloro-5-(o-methoxyphenoxy)-4-pyrimidinyl]-benzene sulfonamide

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