3-[3-(3-fluoro-4-methylphenyl)-2-oxo-2,3-dihydrooxazol-5-yl]propionaldehyde

Base Information

Chemical Name:3-[3-(3-fluoro-4-methylphenyl)-2-oxo-2,3-dihydrooxazol-5-yl]propionaldehyde
CAS No.:1619974-55-8
Molecular Formula:C₁₃H₁₂FNO₃
Molecular Weight:249.242
Hs Code.:

Synonyms:3-[3-(3-fluoro-4-methylphenyl)-2-oxo-2,3-dihydrooxazol-5-yl]propionaldehyde

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Chemical Property of 3-[3-(3-fluoro-4-methylphenyl)-2-oxo-2,3-dihydrooxazol-5-yl]propionaldehyde

Chemical Property:

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Technology Process of 3-[3-(3-fluoro-4-methylphenyl)-2-oxo-2,3-dihydrooxazol-5-yl]propionaldehyde

There total 5 articles about 3-[3-(3-fluoro-4-methylphenyl)-2-oxo-2,3-dihydrooxazol-5-yl]propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1619974-54-7
3-(3-fluoro-4-methylphenyl)-5-(3-hydroxypropyl)-3H-oxazol-2-one

: 1619974-55-8
3-[3-(3-fluoro-4-methylphenyl)-2-oxo-2,3-dihydrooxazol-5-yl]propionaldehyde

Guidance literature:: With sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide; at 10 - 20 ℃; for 2.08333h;

Reference yield:

: 1619974-52-5
[5-(tert-butyl(dimethyl)silanyloxy)pent-1-ynyl]-(3-fluoro-4-methylphenyl)carbamic acid tert-butyl ester

: 1619974-55-8
3-[3-(3-fluoro-4-methylphenyl)-2-oxo-2,3-dihydrooxazol-5-yl]propionaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: (triphenylphosphine)gold(I) chloride; silver hexafluoroantimonate / dichloromethane; acetonitrile / 40 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2.08 h / 10 - 20 °C

With silver hexafluoroantimonate; (triphenylphosphine)gold(I) chloride; tetrabutyl ammonium fluoride; sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1619974-53-6
5-[3-(tert-butyl(dimethyl)silanyloxy)-propyl]-3-(3-fluoro-4-methylphenyl)-3H-oxazol-2-one

: 1619974-55-8
3-[3-(3-fluoro-4-methylphenyl)-2-oxo-2,3-dihydrooxazol-5-yl]propionaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2.08 h / 10 - 20 °C

With tetrabutyl ammonium fluoride; sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;