(S)-3-Benzyloxycarbonylamino-2-(4-bromo-benzoylamino)-propionic acid methyl ester

Base Information

• Chemical Name: (S)-3-Benzyloxycarbonylamino-2-(4-bromo-benzoylamino)-propionic acid methyl ester
• CAS No.: 223778-12-9
• Molecular Formula: C₁₉H₁₉BrN₂O₅
• Molecular Weight: 435.274
• Mol file: 223778-12-9.mol

Synonyms:(S)-3-Benzyloxycarbonylamino-2-(4-bromo-benzoylamino)-propionic acid methyl ester

Chemical Property of (S)-3-Benzyloxycarbonylamino-2-(4-bromo-benzoylamino)-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-Benzyloxycarbonylamino-2-(4-bromo-benzoylamino)-propionic acid methyl ester

There total 1 articles about (S)-3-Benzyloxycarbonylamino-2-(4-bromo-benzoylamino)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Nβ-Z-Dap-OMe*HCl (71749-02-5) + 4-chlorobenzoyl chloride (586-75-4) → (S)-3-Benzyloxycarbonylamino-2-(4-bromo-benzoylamino)-propionic acid methyl ester (223778-12-9)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; Yield given; a) 0 deg C, 2 h, b) RT, overnight;

DOI:10.1021/ja9842114

Reference yield:

(S)-3-Benzyloxycarbonylamino-2-(4-bromo-benzoylamino)-propionic acid methyl ester (223778-12-9) → methyl 2-(4-bromobenzamido)acrylate

Guidance literature:

Multi-step reaction with 2 steps

1: 25 percent HBr, AcOH / 2 h / Ambient temperature

2: CH₃I, KHCO₃ / methanol; dimethylformamide / 6 h / Ambient temperature

With hydrogen bromide; potassium hydrogencarbonate; acetic acid; methyl iodide; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/ja9842114

Reference yield:

(S)-3-Benzyloxycarbonylamino-2-(4-bromo-benzoylamino)-propionic acid methyl ester (223778-12-9) → (S)-3-Amino-2-(4-bromo-benzoylamino)-propionic acid methyl ester; hydrobromide

Guidance literature:

With hydrogen bromide; acetic acid; for 2h; Ambient temperature;

DOI:10.1021/ja9842114

upstream raw materials:

N^β-Z-Dap-OMe*HCl

4-chlorobenzoyl chloride