4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)benzenesulfonamide

Base Information

Chemical Name:4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)benzenesulfonamide
CAS No.:1446233-53-9
Molecular Formula:C₂₀H₁₅F₂N₃O₄S
Molecular Weight:431.42
Hs Code.:

Synonyms:4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)benzenesulfonamide

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Chemical Property of 4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)benzenesulfonamide

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Technology Process of 4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)benzenesulfonamide

There total 11 articles about 4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.5%

: 1445993-89-4
6-methyl-1-[(4-methylphenyl)sulfonyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

: 1446236-07-2
4-(2,4-difluorophenoxy)-3-iodobenzenesulfonamide

: 1446233-53-9
4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)benzenesulfonamide

Guidance literature:: 6-methyl-1-[(4-methylphenyl)sulfonyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one; 4-(2,4-difluorophenoxy)-3-iodobenzenesulfonamide; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride; In methanol; 1,2-dimethoxyethane; at 150 ℃; for 0.0833333h; Microwave irradiation;

With lithium hydroxide monohydrate; water; In 1,4-dioxane; at 120 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: C₂₇H₂₁F₂N₃O₆S₂

: 1446233-53-9
4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)benzenesulfonamide

Guidance literature:: With lithium hydroxide monohydrate; In 1,4-dioxane; water; at 120 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1445993-85-0
4-bromo-7-methoxy-1-(4-methylbenzenesulfonyl)pyrrolo[2,3-c]pyridine

: 1446233-53-9
4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / 1,4-dioxane / 16 h / 40 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Inert atmosphere

2.2: 3 h / 20 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; XPhos / 1 h / Inert atmosphere

3.2: 6 h / 80 °C / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride / 1,2-dimethoxyethane; methanol / 0.08 h / 150 °C / Microwave irradiation

4.2: 0.5 h / 120 °C / Microwave irradiation

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium hydride; cesium fluoride; XPhos; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; N,N-dimethyl-formamide; mineral oil;