2-(N-(1-(2',4'-dichlorobiphenyl-4-yl)cyclobutyl)-4-(difluoromethoxy) phenylsulfonamido)acetic acid

Base Information

Chemical Name:2-(N-(1-(2',4'-dichlorobiphenyl-4-yl)cyclobutyl)-4-(difluoromethoxy) phenylsulfonamido)acetic acid
CAS No.:1331730-05-2
Molecular Formula:C₂₅H₂₁Cl₂F₂NO₅S
Molecular Weight:556.414
Hs Code.:

Synonyms:2-(N-(1-(2',4'-dichlorobiphenyl-4-yl)cyclobutyl)-4-(difluoromethoxy) phenylsulfonamido)acetic acid

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Chemical Property of 2-(N-(1-(2',4'-dichlorobiphenyl-4-yl)cyclobutyl)-4-(difluoromethoxy) phenylsulfonamido)acetic acid

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Technology Process of 2-(N-(1-(2',4'-dichlorobiphenyl-4-yl)cyclobutyl)-4-(difluoromethoxy) phenylsulfonamido)acetic acid

There total 4 articles about 2-(N-(1-(2',4'-dichlorobiphenyl-4-yl)cyclobutyl)-4-(difluoromethoxy) phenylsulfonamido)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1331730-03-0
2-(N-(1-(4-bromophenyl)cyclobutyl)-4-(difluoromethoxy)phenylsulfonamido)acetic acid

: 68716-47-2
2,4-dichlorophenylboronic acid

: 1331730-05-2
2-(N-(1-(2',4'-dichlorobiphenyl-4-yl)cyclobutyl)-4-(difluoromethoxy) phenylsulfonamido)acetic acid

Guidance literature:: With palladium diacetate; sodium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 0.333333h; Inert atmosphere;
DOI:10.1016/j.bmc.2016.02.006

Reference yield:

: 351003-34-4
4-[(difluoromethyl)oxy]benzenesulfonyl chloride

: 1331730-05-2
2-(N-(1-(2',4'-dichlorobiphenyl-4-yl)cyclobutyl)-4-(difluoromethoxy) phenylsulfonamido)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine / N,N-dimethyl-formamide / 70 °C

1.2: 70 °C

2.1: sodium hydroxide / water; methanol; tetrahydrofuran / 0.33 h / 90 °C

3.1: sodium carbonate; palladium diacetate / N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere

With palladium diacetate; sodium carbonate; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2016.02.006

Reference yield:

: 1331730-52-9
methyl 2-(N-(1-(4-bromophenyl)cyclobutyl)-4-(difluoromethoxy)phenylsulfonamido)acetate

: 1331730-05-2
2-(N-(1-(2',4'-dichlorobiphenyl-4-yl)cyclobutyl)-4-(difluoromethoxy) phenylsulfonamido)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water; methanol; tetrahydrofuran / 0.33 h / 90 °C

2: sodium carbonate; palladium diacetate / N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere

With palladium diacetate; sodium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2016.02.006