Maniwamycin B

Base Information

Chemical Name:Maniwamycin B
CAS No.:122547-71-1
Molecular Formula:C₁₀H₂₀N₂O₂
Molecular Weight:200.281
Hs Code.:
Wikidata:Q105359595
Mol file:122547-71-1.mol

Synonyms:2-hydroxybutane-3-NNO-azoxy-1'-(1'-hexene);maniwamycin B

Suppliers and Price of Maniwamycin B

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
MANIWAMYCIN B 95.00%
5MG
$ 505.73

Total 2 raw suppliers

Chemical Property of Maniwamycin B

Chemical Property:

Vapor Pressure:0.000109mmHg at 25°C
Boiling Point:300.7°C at 760 mmHg
Flash Point:135.7°C
PSA：61.34000
Density:0.99g/cm³
LogP:2.94530
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:200.152477885
Heavy Atom Count:14
Complexity:202

Purity/Quality:

95% ^*data from raw suppliers

MANIWAMYCIN B 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCC=C[N+](=NC(C)C(C)O)[O-]
Isomeric SMILES:CCCC/C=C/[N+](=N[C@@H](C)[C@H](C)O)[O-]

Technology Process of Maniwamycin B

There total 28 articles about Maniwamycin B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 154695-66-6
Benzoic acid (1S,2S)-2-[((E)-hex-1-enyl)-ONN-azoxy]-1-methyl-propyl ester

: 122547-71-1
maniwamycin B

Guidance literature:: With potassium carbonate; In methanol; for 3.5h; Ambient temperature;
DOI:10.1016/S0040-4039(00)61737-9

Reference yield:

: 591-78-6
n-hexan-2-one

: 122547-71-1
maniwamycin B

Guidance literature:: Multi-step reaction with 15 steps

1: 65 percent / LDA / tetrahydrofuran / -78 °C

2: NaBH₄ / methanol; tetrahydrofuran / 0.5 h / Ambient temperature

3: 100 percent / Et₃N / CH₂Cl₂ / 0.67 h / 0 °C

4: 96 percent / 1.) BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / 1.) -78 deg C, 10 min, 2.) room temp., 2 d

5: 5 molpercent H₂SO₄ / dioxane / 0.33 h / Ambient temperature

6: DMAP / pyridine / 24 h / 40 °C

7: 2percent HCl / methanol / 0.5 h / Ambient temperature

8: H₂ / Pd-C / acetic acid; ethanol / 2 h / Ambient temperature

9: air, 10 molpercent Cu(OAc)2 / acetic acid; H₂O; ethanol / 0.67 h / Ambient temperature

10: 87 percent / 3.63M t-BuOOH, 40 molpercent VO(acac)2 / CH₂Cl₂; toluene / 0.33 h / 0 °C

11: Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

12: DBU / toluene / 1.67 h / 40 °C

13: K₂CO₃ / methanol / 1 h / Ambient temperature

14: 70 percent / PPh₃, DEAD / tetrahydrofuran / 0.67 h / 0 °C

15: 50 percent / K₂CO₃ / methanol / 3.5 h / Ambient temperature

With hydrogenchloride; tert.-butylhydroperoxide; sodium tetrahydroborate; n-butyllithium; copper diacetate; bis(acetylacetonate)oxovanadium; air; sulfuric acid; hydrogen; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; lithium diisopropyl amide; diethylazodicarboxylate; dmap; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane; water; acetic acid; toluene;
DOI:10.1016/S0040-4039(00)61737-9

Reference yield:

: 591-78-6
n-hexan-2-one

: 154695-65-5,122547-71-1
(2R,3S)-3-[((E)-Hex-1-enyl)-ONN-azoxy]-butan-2-ol

Guidance literature:: Multi-step reaction with 13 steps

1: 65 percent / LDA / tetrahydrofuran / -78 °C

2: NaBH₄ / methanol; tetrahydrofuran / 0.5 h / Ambient temperature

3: 100 percent / Et₃N / CH₂Cl₂ / 0.67 h / 0 °C

4: 96 percent / 1.) BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / 1.) -78 deg C, 10 min, 2.) room temp., 2 d

5: 5 molpercent H₂SO₄ / dioxane / 0.33 h / Ambient temperature

6: DMAP / pyridine / 24 h / 40 °C

7: 2percent HCl / methanol / 0.5 h / Ambient temperature

8: H₂ / Pd-C / acetic acid; ethanol / 2 h / Ambient temperature

9: air, 10 molpercent Cu(OAc)2 / acetic acid; H₂O; ethanol / 0.67 h / Ambient temperature

10: 87 percent / 3.63M t-BuOOH, 40 molpercent VO(acac)2 / CH₂Cl₂; toluene / 0.33 h / 0 °C

11: Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

12: DBU / toluene / 1.67 h / 40 °C

13: K₂CO₃ / methanol / 1 h / Ambient temperature

With hydrogenchloride; tert.-butylhydroperoxide; sodium tetrahydroborate; n-butyllithium; copper diacetate; bis(acetylacetonate)oxovanadium; air; sulfuric acid; hydrogen; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium diisopropyl amide; dmap; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane; water; acetic acid; toluene;
DOI:10.1016/S0040-4039(00)61737-9