2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-[2-((4R,6R)-6-methoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-3-methyl-6-propyl-cyclohexylmethyl ester

Base Information

Chemical Name:2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-[2-((4R,6R)-6-methoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-3-methyl-6-propyl-cyclohexylmethyl ester
CAS No.:135716-22-2
Molecular Formula:C₂₈H₅₀O₆
Molecular Weight:482.701
Hs Code.:

2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-[2-((4R,6R)-6-methoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-3-methyl-6-propyl-cyclohexylmethyl ester

Synonyms:2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-[2-((4R,6R)-6-methoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-3-methyl-6-propyl-cyclohexylmethyl ester

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Chemical Property of 2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-[2-((4R,6R)-6-methoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-3-methyl-6-propyl-cyclohexylmethyl ester

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Technology Process of 2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-[2-((4R,6R)-6-methoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-3-methyl-6-propyl-cyclohexylmethyl ester

There total 21 articles about 2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-[2-((4R,6R)-6-methoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-3-methyl-6-propyl-cyclohexylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 136491-81-1
2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-[2-((4R,6R)-6-carboxymethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-3-methyl-6-propyl-cyclohexylmethyl ester

: 135716-22-2
2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-[2-((4R,6R)-6-methoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-3-methyl-6-propyl-cyclohexylmethyl ester

Guidance literature:: In diethyl ether; at 0 ℃;
DOI:10.1016/0040-4039(91)80587-V

Reference yield:

: 53716-84-0
(1S,3S,5R)-6,8-dioxabicyclo[3.2.1]octan-3-yl acetate

: 135716-22-2
2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-[2-((4R,6R)-6-methoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-3-methyl-6-propyl-cyclohexylmethyl ester

Guidance literature:: Multi-step reaction with 14 steps

1: BF₃*Et₂O

2: MeONa

3: ImH / dimethylformamide

4: lithium 4,4'-di-tert-butylbiphenyl / tetrahydrofuran / -78 °C

5: 1.) NaH, CS₂, 2.) MeI, 3.) Bu₃SnH / 2.) THF

6: aq. HF / acetonitrile

7: 48 h / 40 °C

9: LiI / hexamethylphosphoric acid triamide; toluene / Heating

10: Zn / methanol / Heating

11: K₂CO₃ / methanol / Ambient temperature

12: CSA / acetone

13: O₃, Ph₃P / CH₂Cl₂

14: 1.) KMnO₄, NaH₂PO₄ / 1.) t-BuOH, H₂O

With 1H-imidazole; carbon disulfide; potassium permanganate; sodium dihydrogenphosphate; boron trifluoride diethyl etherate; hydrogen fluoride; tri-n-butyl-tin hydride; sodium methylate; sodium hydride; lithium 4,4′-di-tert-butylbiphenylide; potassium carbonate; ozone; triphenylphosphine; lithium iodide; zinc; methyl iodide; camphor-10-sulfonic acid; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1016/S0040-4039(00)75798-4

Reference yield:

: Acetic acid (2S,4S)-2-hydroxymethyl-6-phenylsulfanyl-tetrahydro-pyran-4-yl ester

: 135716-22-2
2,2-Dimethyl-butyric acid (1S,2S,3S,6R)-2-[2-((4R,6R)-6-methoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-3-methyl-6-propyl-cyclohexylmethyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: MeONa

2: ImH / dimethylformamide

3: lithium 4,4'-di-tert-butylbiphenyl / tetrahydrofuran / -78 °C

4: 1.) NaH, CS₂, 2.) MeI, 3.) Bu₃SnH / 2.) THF

5: aq. HF / acetonitrile

6: 48 h / 40 °C

8: LiI / hexamethylphosphoric acid triamide; toluene / Heating

9: Zn / methanol / Heating

10: K₂CO₃ / methanol / Ambient temperature

11: CSA / acetone

12: O₃, Ph₃P / CH₂Cl₂

13: 1.) KMnO₄, NaH₂PO₄ / 1.) t-BuOH, H₂O

With 1H-imidazole; carbon disulfide; potassium permanganate; sodium dihydrogenphosphate; hydrogen fluoride; tri-n-butyl-tin hydride; sodium methylate; sodium hydride; lithium 4,4′-di-tert-butylbiphenylide; potassium carbonate; ozone; triphenylphosphine; lithium iodide; zinc; methyl iodide; camphor-10-sulfonic acid; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1016/S0040-4039(00)75798-4