4-Benzyloxy-2-((R)-4-oxo-tetrahydro-thiopyran-2-ylsulfanylmethyl)-butyraldehyde

Base Information

Chemical Name:4-Benzyloxy-2-((R)-4-oxo-tetrahydro-thiopyran-2-ylsulfanylmethyl)-butyraldehyde
CAS No.:78442-70-3
Molecular Formula:C₁₇H₂₂O₃S₂
Molecular Weight:338.492
Hs Code.:

Synonyms:4-Benzyloxy-2-((R)-4-oxo-tetrahydro-thiopyran-2-ylsulfanylmethyl)-butyraldehyde

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Chemical Property of 4-Benzyloxy-2-((R)-4-oxo-tetrahydro-thiopyran-2-ylsulfanylmethyl)-butyraldehyde

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Technology Process of 4-Benzyloxy-2-((R)-4-oxo-tetrahydro-thiopyran-2-ylsulfanylmethyl)-butyraldehyde

There total 7 articles about 4-Benzyloxy-2-((R)-4-oxo-tetrahydro-thiopyran-2-ylsulfanylmethyl)-butyraldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-2-(4-Benzyloxy-2-dimethoxymethyl-butylsulfanyl)-4,4-dimethoxy-tetrahydro-thiopyran

: 78442-70-3
4-Benzyloxy-2-((R)-4-oxo-tetrahydro-thiopyran-2-ylsulfanylmethyl)-butyraldehyde

Guidance literature:: With acetic acid; In water; Ambient temperature;
DOI:10.1021/ja00401a049

Reference yield:

: 31600-42-7
methyl 4-(benzyloxy)butanoate

: 78442-70-3
4-Benzyloxy-2-((R)-4-oxo-tetrahydro-thiopyran-2-ylsulfanylmethyl)-butyraldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) i-PrNLi / 1.) THF, -78 deg C

2: conc. H₂SO₄ / methanol / 25 °C

3: LiAlH₄ / diethyl ether / -20 deg C -> 0 deg C

4: pyridine / 0 °C

5: NaH / tetrahydrofuran; dimethylsulfoxide / Ambient temperature

6: AcOH / H₂O / Ambient temperature

With pyridine; lithium aluminium tetrahydride; sulfuric acid; sodium hydride; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; water; dimethyl sulfoxide;
DOI:10.1021/ja00401a049

Reference yield:

: 10385-30-5
4-(benzyloxy)butanoic acid

: 78442-70-3
4-Benzyloxy-2-((R)-4-oxo-tetrahydro-thiopyran-2-ylsulfanylmethyl)-butyraldehyde

Guidance literature:: Multi-step reaction with 7 steps

1: conc. H₂SO₄ / 25 °C

2: 1.) i-PrNLi / 1.) THF, -78 deg C

3: conc. H₂SO₄ / methanol / 25 °C

4: LiAlH₄ / diethyl ether / -20 deg C -> 0 deg C

5: pyridine / 0 °C

6: NaH / tetrahydrofuran; dimethylsulfoxide / Ambient temperature

7: AcOH / H₂O / Ambient temperature

With pyridine; lithium aluminium tetrahydride; sulfuric acid; sodium hydride; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; water; dimethyl sulfoxide;
DOI:10.1021/ja00401a049