C₇₀H₁₁₆O₁₀Si₄

Base Information

• Chemical Name: C₇₀H₁₁₆O₁₀Si₄
• CAS No.: 908866-25-1
• Molecular Formula: C₇₀H₁₁₆O₁₀Si₄
• Molecular Weight: 1230.03

Synonyms:C₇₀H₁₁₆O₁₀Si₄

Chemical Property of C₇₀H₁₁₆O₁₀Si₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of C₇₀H₁₁₆O₁₀Si₄

There total 58 articles about C₇₀H₁₁₆O₁₀Si₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C70H118O10Si4 → C70H116O10Si4 (908866-25-1)

Guidance literature:

With N-methyl-2-indolinone; 4 A molecular sieve; tetrapropylammonium perruthennate; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/ja062524q

Reference yield:

(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-2-hydroxymethyl-oxepan-3-ol (908866-07-9) → C70H116O10Si4 (908866-25-1)

Guidance literature:

Multi-step reaction with 29 steps

1.1: 2,6-lutidine / CH₂Cl₂ / 0.5 h / -78 °C

1.2: CH₂Cl₂ / 0.75 h / -78 - 20 °C

2.1: 272.1 mg / CuBr / diethyl ether / 1 h / 0 °C

3.1: OsO₄; aq. 4-methylmorpholine N-oxide / tetrahydrofuran; 2-methyl-propan-2-ol / 3 h / 20 °C

3.2: NaIO₄ / tetrahydrofuran; 2-methyl-propan-2-ol / 3 h / 20 °C

4.1: BF₃*OEt₂ / CH₂Cl₂ / 0.67 h / -78 - 0 °C

5.1: 1.39 g / TBAF / tetrahydrofuran / 20 °C

6.1: 1.57 g / 4-methylmorpholine / CH₂Cl₂ / 36 h / 20 °C

7.1: 1.27 g / NaHCO₃; MeI / acetonitrile; H₂O / 35 °C

8.1: SmI₂; MeOH / tetrahydrofuran / 0.5 h / 20 °C

8.2: 84 percent / p-TsOH*H₂O / toluene / 1 h / 80 °C

9.1: DIBALH / CH₂Cl₂; hexane / 0.5 h / -78 °C

10.1: NaHMDS / tetrahydrofuran / 0.5 h / 0 °C

10.2: 167.6 mg / tetrahydrofuran / 0.5 h / 0 - 20 °C

11.1: 97 percent / tetra-n-propylammonium perruthenate; 4-methylmorpholine N-oxide; 4 Angstroem molecular sieves / CH₂Cl₂ / 0.83 h / 20 °C

12.1: 89 percent / tetrahydrofuran; diethyl ether / 1 h / -78 - 0 °C

13.1: 100 percent / Et₃N / CH₂Cl₂ / 4 h / 20 °C

14.1: 9-BBN / tetrahydrofuran / 20 °C

14.2: aq. H₂O₂; NaHCO₃ / tetrahydrofuran / 3 h / 20 °C

15.1: H₂ / Pd(OH)2/C / methanol / 2.25 h / 20 °C

16.1: 375.3 mg / PPTS / CH₂Cl₂ / 1 h / 20 °C

17.1: t-BuOK / tetrahydrofuran / 0.33 h / 20 °C

17.2: n-Bu₄NI / tetrahydrofuran / 0.83 h / 20 °C

18.1: 356.6 g / DIBALH / CH₂Cl₂; hexane / 1 h / -78 - 0 °C

19.1: I₂; Ph₃P; imidazole / benzene / 1 h / 20 °C

20.1: 890.2 mg / t-BuOK / tetrahydrofuran / 0.67 h / 0 °C

21.1: 9-BBN / tetrahydrofuran / 2.5 h / 20 °C

21.2: aq. Cs₂CO₃ / tetrahydrofuran / 0.33 h / 20 °C

21.3: Pd(PPh₃)4 / tetrahydrofuran; dimethylformamide / 50 °C

22.1: BH₃*SMe₂ / tetrahydrofuran / 1 h / 0 °C

22.2: 1.35 g / aq. H₂O₂; NaHCO₃ / tetrahydrofuran / 2.5 h / 20 °C

23.1: 98 percent / tetra-n-propylammonium perruthenate; 4-methylmorpholine N-oxide; 4 Angstroem molecular sieves / CH₂Cl₂ / 1.17 h / 0 °C

24.1: Et₃N; LiHMDS / tetrahydrofuran / 0.58 h / -78 °C

25.1: 1.90 g / aq. 4-methylmorpholine N-oxide; OsO₄ / 2-methyl-propan-2-ol; tetrahydrofuran / 9 h / 20 °C

26.1: 76 percent / DIBALH / tetrahydrofuran; hexane / 1 h / -78 °C

27.1: Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

28.1: DDQ; phosphate buffer / CH₂Cl₂ / 1 h / 20 °C / pH 7

29.1: 246.0 mg / tetra-n-propylammonium perruthenate; 4-methylmorpholine N-oxide; 4 Angstroem molecular sieves / CH₂Cl₂ / 2 h / 20 °C

With 4-methyl-morpholine; 1H-imidazole; 2,6-dimethylpyridine; methanol; osmium(VIII) oxide; 9-borabicyclo[3.3.1]nonane dimer; phosphate buffer; samarium diiodide; tetrapropylammonium perruthennate; dimethylsulfide borane complex; 4 A molecular sieve; boron trifluoride diethyl etherate; potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; iodine; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; copper(I) bromide; lithium hexamethyldisilazane; methyl iodide; palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; acetonitrile; tert-butyl alcohol; benzene; 6.1: Michael reaction / 10.2: Wittig reaction / 21.2: Suzuki- Miyaura coupling;

DOI:10.1021/ja066772y

Reference yield:

(2R,4aR,6S,7R,9aS)-7-Benzyloxy-6-benzyloxymethyl-2-phenyl-hexahydro-1,3,5-trioxa-benzocycloheptene → C70H116O10Si4 (908866-25-1)

Guidance literature:

Multi-step reaction with 30 steps

1.1: 9.10 g / CSA / methanol; CHCl₃ / 20 °C

2.1: 2,6-lutidine / CH₂Cl₂ / 0.5 h / -78 °C

2.2: CH₂Cl₂ / 0.75 h / -78 - 20 °C

3.1: 272.1 mg / CuBr / diethyl ether / 1 h / 0 °C

4.1: OsO₄; aq. 4-methylmorpholine N-oxide / tetrahydrofuran; 2-methyl-propan-2-ol / 3 h / 20 °C

4.2: NaIO₄ / tetrahydrofuran; 2-methyl-propan-2-ol / 3 h / 20 °C

5.1: BF₃*OEt₂ / CH₂Cl₂ / 0.67 h / -78 - 0 °C

6.1: 1.39 g / TBAF / tetrahydrofuran / 20 °C

7.1: 1.57 g / 4-methylmorpholine / CH₂Cl₂ / 36 h / 20 °C

8.1: 1.27 g / NaHCO₃; MeI / acetonitrile; H₂O / 35 °C

9.1: SmI₂; MeOH / tetrahydrofuran / 0.5 h / 20 °C

9.2: 84 percent / p-TsOH*H₂O / toluene / 1 h / 80 °C

10.1: DIBALH / CH₂Cl₂; hexane / 0.5 h / -78 °C

11.1: NaHMDS / tetrahydrofuran / 0.5 h / 0 °C

11.2: 167.6 mg / tetrahydrofuran / 0.5 h / 0 - 20 °C

12.1: 97 percent / tetra-n-propylammonium perruthenate; 4-methylmorpholine N-oxide; 4 Angstroem molecular sieves / CH₂Cl₂ / 0.83 h / 20 °C

13.1: 89 percent / tetrahydrofuran; diethyl ether / 1 h / -78 - 0 °C

14.1: 100 percent / Et₃N / CH₂Cl₂ / 4 h / 20 °C

15.1: 9-BBN / tetrahydrofuran / 20 °C

15.2: aq. H₂O₂; NaHCO₃ / tetrahydrofuran / 3 h / 20 °C

16.1: H₂ / Pd(OH)2/C / methanol / 2.25 h / 20 °C

17.1: 375.3 mg / PPTS / CH₂Cl₂ / 1 h / 20 °C

18.1: t-BuOK / tetrahydrofuran / 0.33 h / 20 °C

18.2: n-Bu₄NI / tetrahydrofuran / 0.83 h / 20 °C

19.1: 356.6 g / DIBALH / CH₂Cl₂; hexane / 1 h / -78 - 0 °C

20.1: I₂; Ph₃P; imidazole / benzene / 1 h / 20 °C

21.1: 890.2 mg / t-BuOK / tetrahydrofuran / 0.67 h / 0 °C

22.1: 9-BBN / tetrahydrofuran / 2.5 h / 20 °C

22.2: aq. Cs₂CO₃ / tetrahydrofuran / 0.33 h / 20 °C

22.3: Pd(PPh₃)4 / tetrahydrofuran; dimethylformamide / 50 °C

23.1: BH₃*SMe₂ / tetrahydrofuran / 1 h / 0 °C

23.2: 1.35 g / aq. H₂O₂; NaHCO₃ / tetrahydrofuran / 2.5 h / 20 °C

24.1: 98 percent / tetra-n-propylammonium perruthenate; 4-methylmorpholine N-oxide; 4 Angstroem molecular sieves / CH₂Cl₂ / 1.17 h / 0 °C

25.1: Et₃N; LiHMDS / tetrahydrofuran / 0.58 h / -78 °C

26.1: 1.90 g / aq. 4-methylmorpholine N-oxide; OsO₄ / 2-methyl-propan-2-ol; tetrahydrofuran / 9 h / 20 °C

27.1: 76 percent / DIBALH / tetrahydrofuran; hexane / 1 h / -78 °C

28.1: Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

29.1: DDQ; phosphate buffer / CH₂Cl₂ / 1 h / 20 °C / pH 7

30.1: 246.0 mg / tetra-n-propylammonium perruthenate; 4-methylmorpholine N-oxide; 4 Angstroem molecular sieves / CH₂Cl₂ / 2 h / 20 °C

With 4-methyl-morpholine; 1H-imidazole; 2,6-dimethylpyridine; methanol; osmium(VIII) oxide; 9-borabicyclo[3.3.1]nonane dimer; phosphate buffer; samarium diiodide; tetrapropylammonium perruthennate; dimethylsulfide borane complex; 4 A molecular sieve; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; iodine; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; copper(I) bromide; lithium hexamethyldisilazane; methyl iodide; palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; chloroform; water; acetonitrile; tert-butyl alcohol; benzene; 7.1: Michael reaction / 11.2: Wittig reaction / 22.2: Suzuki- Miyaura coupling;

DOI:10.1021/ja066772y

upstream raw materials:

((2R,4aR,6S,7R,9aS)-7-Benzyloxy-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-6-yl)-methanol

(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-2-hydroxymethyl-oxepan-3-ol

(2S,3S)-6-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-hexane-1,3-diol

(2R,3S,5S,6S)-6-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-2,5-dimethyl-2-vinyl-tetrahydro-pyran-3-ol

Downstream raw materials:

C₆₀H₉₂O₉SSi₂

C₅₈H₉₈O₉Si₃

C₆₅H₁₀₄O₉Si₃

C₆₄H₁₁₂O₉Si₄

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