(E)-2-[2-(2-amino-4-trifluoromethylphenyl)-1-methylvinyl]pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Name:(E)-2-[2-(2-amino-4-trifluoromethylphenyl)-1-methylvinyl]pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:1422193-30-3
Molecular Formula:C₁₉H₂₅F₃N₂O₂
Molecular Weight:370.415
Hs Code.:

Synonyms:(E)-2-[2-(2-amino-4-trifluoromethylphenyl)-1-methylvinyl]pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (E)-2-[2-(2-amino-4-trifluoromethylphenyl)-1-methylvinyl]pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of (E)-2-[2-(2-amino-4-trifluoromethylphenyl)-1-methylvinyl]pyrrolidine-1-carboxylic acid tert-butyl ester

There total 9 articles about (E)-2-[2-(2-amino-4-trifluoromethylphenyl)-1-methylvinyl]pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1196972-92-5
5-(trifluoromethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine

: C₁₃H₂₀F₃NO₅S

: 1422193-30-3
(E)-2-[2-(2-amino-4-trifluoromethylphenyl)-1-methylvinyl]pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydroxide; In 1,4-dioxane; water; at 120 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol400137q

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 1422193-30-3
(E)-2-[2-(2-amino-4-trifluoromethylphenyl)-1-methylvinyl]pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 15 h / 0 - 20 °C / Inert atmosphere

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

2.2: 15 h / 20 °C / Inert atmosphere

3.1: diethyl ether / 1 h / 0 °C / Inert atmosphere

4.1: potassium tert-butylate / diethyl ether / 0.5 h / 0 °C / Inert atmosphere

4.2: 2 h / Inert atmosphere

5.1: acetic acid / diethyl ether / 24 h / Inert atmosphere

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - 20 °C / Inert atmosphere

6.2: 15 h / Inert atmosphere

7.1: sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 12 h / 120 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium tert-butylate; sodium hydrogencarbonate; acetic acid; 1,1'-carbonyldiimidazole; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; 7.1: |Suzuki Coupling;
DOI:10.1021/ol400137q

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1422193-30-3
(E)-2-[2-(2-amino-4-trifluoromethylphenyl)-1-methylvinyl]pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

1.2: 15 h / 20 °C / Inert atmosphere

2.1: diethyl ether / 1 h / 0 °C / Inert atmosphere

3.1: potassium tert-butylate / diethyl ether / 0.5 h / 0 °C / Inert atmosphere

3.2: 2 h / Inert atmosphere

4.1: acetic acid / diethyl ether / 24 h / Inert atmosphere

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - 20 °C / Inert atmosphere

5.2: 15 h / Inert atmosphere

6.1: sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 12 h / 120 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium tert-butylate; acetic acid; 1,1'-carbonyldiimidazole; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; 6.1: |Suzuki Coupling;
DOI:10.1021/ol400137q