2R,3R-2-benzyloxymethyl-2-methoxycarbonyl-1,4-dioxaspiro<4.4>nonane-3-carboxaldehyde

Base Information

Chemical Name:2R,3R-2-benzyloxymethyl-2-methoxycarbonyl-1,4-dioxaspiro<4.4>nonane-3-carboxaldehyde
CAS No.:208175-30-8
Molecular Formula:C₁₈H₂₂O₆
Molecular Weight:334.369
Hs Code.:

Synonyms:2R,3R-2-benzyloxymethyl-2-methoxycarbonyl-1,4-dioxaspiro<4.4>nonane-3-carboxaldehyde

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Chemical Property of 2R,3R-2-benzyloxymethyl-2-methoxycarbonyl-1,4-dioxaspiro<4.4>nonane-3-carboxaldehyde

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Technology Process of 2R,3R-2-benzyloxymethyl-2-methoxycarbonyl-1,4-dioxaspiro<4.4>nonane-3-carboxaldehyde

There total 7 articles about 2R,3R-2-benzyloxymethyl-2-methoxycarbonyl-1,4-dioxaspiro<4.4>nonane-3-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 208175-28-4
2R,3S-2-benzyloxymethyl-3-hydroxymethyl-2-methoxycarbonyl-1,4-dioxaspiro<4.4>nonane

: 208175-30-8
2R,3R-2-benzyloxymethyl-2-methoxycarbonyl-1,4-dioxaspiro<4.4>nonane-3-carboxaldehyde

Guidance literature:: DOI:10.1021/jo980301f

Reference yield:

: 208175-26-2
2R,3R-2-benzyloxymethyl-2,3-bis(methoxycarbonyl)-1,4-dioxaspiro<4.4>nonane

: 208175-30-8
2R,3R-2-benzyloxymethyl-2-methoxycarbonyl-1,4-dioxaspiro<4.4>nonane-3-carboxaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / DIBAL-H / tetrahydrofuran; toluene / -78 - 0 °C

2: 80 percent / (COCl)2, DMSO, DIPEA / CH₂Cl₂ / -78 - 20 °C

With oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jo990046e

Reference yield:

: 198691-38-2
dimethyl 2,3-O-cyclopentylidene-L-tartrate

: 208175-30-8
2R,3R-2-benzyloxymethyl-2-methoxycarbonyl-1,4-dioxaspiro<4.4>nonane-3-carboxaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / LDA / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 - -5 °C

2: 75 percent / DIBAL-H / tetrahydrofuran; toluene / -78 - 0 °C

3: 80 percent / (COCl)2, DMSO, DIPEA / CH₂Cl₂ / -78 - 20 °C

With oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; toluene;
DOI:10.1021/jo990046e