1-acetoxy-3-(4-nitrobenzyloxycarbonyloxy)-2-(4-nitrophenyl)propane

Base Information

• Chemical Name: 1-acetoxy-3-(4-nitrobenzyloxycarbonyloxy)-2-(4-nitrophenyl)propane
• CAS No.: 131605-53-3
• Molecular Formula: C₁₉H₁₈N₂O₉
• Molecular Weight: 418.36
• Mol file: 131605-53-3.mol

Synonyms:1-acetoxy-3-(4-nitrobenzyloxycarbonyloxy)-2-(4-nitrophenyl)propane

Chemical Property of 1-acetoxy-3-(4-nitrobenzyloxycarbonyloxy)-2-(4-nitrophenyl)propane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-acetoxy-3-(4-nitrobenzyloxycarbonyloxy)-2-(4-nitrophenyl)propane

There total 4 articles about 1-acetoxy-3-(4-nitrobenzyloxycarbonyloxy)-2-(4-nitrophenyl)propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

1-acetoxy-3-benzyloxycarbonyloxy-2-phenylpropane (131605-52-2) → 1-acetoxy-3-(4-nitrobenzyloxycarbonyloxy)-2-(4-nitrophenyl)propane (131605-53-3)

Guidance literature:

With nitric acid; at 0 ℃; for 0.5h;

DOI:10.1016/S0040-4020(01)87892-3

Reference yield:

2-phenylpropane-1, 3-diol (1570-95-2) → 1-acetoxy-3-(4-nitrobenzyloxycarbonyloxy)-2-(4-nitrophenyl)propane (131605-53-3)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / 4-dimethylaminopyridine / CH₂Cl₂ / 1 h / Ambient temperature

2: 0.02M phosphate buffer, 1N NaOH / 4.5 h / Ambient temperature; PPL, pH 7

3: 60 percent / pyridine / 0.67 h

4: 30 percent / 90percent nitric acid / 0.5 h / 0 °C

With pyridine; sodium hydroxide; phosphate buffer; nitric acid; triethylamine; dmap; In dichloromethane;

DOI:10.1016/S0040-4020(01)87892-3

Reference yield:

2-phenyl-1,3-propanediol diacetate (98017-92-6) → 1-acetoxy-3-(4-nitrobenzyloxycarbonyloxy)-2-(4-nitrophenyl)propane (131605-53-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 0.02M phosphate buffer, 1N NaOH / 4.5 h / Ambient temperature; PPL, pH 7

2: 60 percent / pyridine / 0.67 h

3: 30 percent / 90percent nitric acid / 0.5 h / 0 °C

With pyridine; sodium hydroxide; phosphate buffer; nitric acid;

DOI:10.1016/S0040-4020(01)87892-3

upstream raw materials:

1-acetoxy-3-benzyloxycarbonyloxy-2-phenylpropane

2-phenylpropane-1, 3-diol

2-phenyl-1,3-propanediol diacetate

(S)-1-acetoxy-3-hydroxy-2-phenylpropane

Downstream raw materials:

(-)-3-acetoxy-2-(4-aminophenyl)propan-1-ol