(2R,4S,5S)-5-amino-6-(3,5-difluorobenzyloxy)-4-hydroxy-2-methylhexanoic acid cyclopropylamide

Base Information

Chemical Name:(2R,4S,5S)-5-amino-6-(3,5-difluorobenzyloxy)-4-hydroxy-2-methylhexanoic acid cyclopropylamide
CAS No.:1067648-49-0
Molecular Formula:C₁₇H₂₄F₂N₂O₃
Molecular Weight:342.386
Hs Code.:

Synonyms:(2R,4S,5S)-5-amino-6-(3,5-difluorobenzyloxy)-4-hydroxy-2-methylhexanoic acid cyclopropylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4S,5S)-5-amino-6-(3,5-difluorobenzyloxy)-4-hydroxy-2-methylhexanoic acid cyclopropylamide

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Technology Process of (2R,4S,5S)-5-amino-6-(3,5-difluorobenzyloxy)-4-hydroxy-2-methylhexanoic acid cyclopropylamide

There total 9 articles about (2R,4S,5S)-5-amino-6-(3,5-difluorobenzyloxy)-4-hydroxy-2-methylhexanoic acid cyclopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1067648-48-9
(2R,4S,5S)-5-azido-6-(3,5-difluorobenzyloxy)-4-hydroxy-2-methylhexanoic acid cyclopropylamide

: 1067648-49-0
(2R,4S,5S)-5-amino-6-(3,5-difluorobenzyloxy)-4-hydroxy-2-methylhexanoic acid cyclopropylamide

Guidance literature:: With water; triphenylphosphine; In methanol; at 20 ℃;
DOI:10.1016/j.ejmech.2009.11.013

Reference yield: 92.0%

: 1067648-49-0
(2R,4S,5S)-5-amino-6-(3,5-difluorobenzyloxy)-4-hydroxy-2-methylhexanoic acid cyclopropylamide

Guidance literature:

Reference yield:

: 1067648-41-2
2,3-dideoxy-2-methyl-D-glucono-1,4-lactone

: 1067648-49-0
(2R,4S,5S)-5-amino-6-(3,5-difluorobenzyloxy)-4-hydroxy-2-methylhexanoic acid cyclopropylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: di(n-butyl)tin oxide / toluene / 5 h / Reflux

1.2: 90 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / -15 - 0 °C

2.2: 0 - 20 °C

3.1: trimethylaluminum / dichloromethane / 1 h / 40 °C

4.1: water; triphenylphosphine / methanol / 20 °C

With di-isopropyl azodicarboxylate; water; trimethylaluminum; di(n-butyl)tin oxide; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1016/j.ejmech.2009.11.013