N-(1-{(1R,3R,4R,7S)-1-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-7-hydroxy-2-oxa-5-azabicyclo[2.2.1]hepta-3-yl}-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide

Base Information

• Chemical Name: N-(1-{(1R,3R,4R,7S)-1-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-7-hydroxy-2-oxa-5-azabicyclo[2.2.1]hepta-3-yl}-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide
• CAS No.: 1262529-27-0
• Molecular Formula: C₃₉H₃₈N₄O₇
• Molecular Weight: 674.753

Synonyms:N-(1-{(1R,3R,4R,7S)-1-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-7-hydroxy-2-oxa-5-azabicyclo[2.2.1]hepta-3-yl}-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide

Chemical Property of N-(1-{(1R,3R,4R,7S)-1-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-7-hydroxy-2-oxa-5-azabicyclo[2.2.1]hepta-3-yl}-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide

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Technology Process of N-(1-{(1R,3R,4R,7S)-1-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-7-hydroxy-2-oxa-5-azabicyclo[2.2.1]hepta-3-yl}-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide

There total 5 articles about N-(1-{(1R,3R,4R,7S)-1-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-7-hydroxy-2-oxa-5-azabicyclo[2.2.1]hepta-3-yl}-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-{1-[(1R,3R,4R,7S)-1-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-7-[(trimethylsilyl)oxy]-2-oxa-5-azabicyclo[2.2.1]hepta-3-yl]-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl}benzamide → N-(1-{(1R,3R,4R,7S)-1-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-7-hydroxy-2-oxa-5-azabicyclo[2.2.1]hepta-3-yl}-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide (1262529-27-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.833333h;

DOI:10.1039/d0ob01970d

Reference yield: 99.0%

→ N-(1-{(1R,3R,4R,7S)-1-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-7-hydroxy-2-oxa-5-azabicyclo[2.2.1]hepta-3-yl}-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide (1262529-27-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.833333h; Cooling with ice;

Reference yield:

C41H37F3N4O8 → N-(1-{(1R,3R,4R,7S)-1-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-7-hydroxy-2-oxa-5-azabicyclo[2.2.1]hepta-3-yl}-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide (1262529-27-0)

Guidance literature:

With pyridine; sodium hydroxide; In ethanol; water; at 0 - 20 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2010.10.089

upstream raw materials:

N-(5-methyl-2-oxo-1H-pyrimidin-4-yl)benzamide

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