(±)-9-[(4-bromo-2,6-difluorophenyl)methyl]-4-cyclopropyl-1-oxa-4,9-diazaspiro[5.5]undecane-3,8-dione

Base Information

Chemical Name:(±)-9-[(4-bromo-2,6-difluorophenyl)methyl]-4-cyclopropyl-1-oxa-4,9-diazaspiro[5.5]undecane-3,8-dione
CAS No.:1429790-75-9
Molecular Formula:C₁₈H₁₉BrF₂N₂O₃
Molecular Weight:429.261
Hs Code.:

Synonyms:(±)-9-[(4-bromo-2,6-difluorophenyl)methyl]-4-cyclopropyl-1-oxa-4,9-diazaspiro[5.5]undecane-3,8-dione

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Chemical Property of (±)-9-[(4-bromo-2,6-difluorophenyl)methyl]-4-cyclopropyl-1-oxa-4,9-diazaspiro[5.5]undecane-3,8-dione

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Technology Process of (±)-9-[(4-bromo-2,6-difluorophenyl)methyl]-4-cyclopropyl-1-oxa-4,9-diazaspiro[5.5]undecane-3,8-dione

There total 6 articles about (±)-9-[(4-bromo-2,6-difluorophenyl)methyl]-4-cyclopropyl-1-oxa-4,9-diazaspiro[5.5]undecane-3,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1429790-73-7
9-[(4-bromo-2,6-difluorophenyl)methyl]-4-cyclopropyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one

: 1429790-75-9
(±)-9-[(4-bromo-2,6-difluorophenyl)methyl]-4-cyclopropyl-1-oxa-4,9-diazaspiro[5.5]undecane-3,8-dione

Guidance literature:: With potassium permanganate; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; at 20 ℃;

Reference yield:

: 1181759-11-4
1,1-dimethylethyl 4-[(cyclopropylamino)methyl]-4-hydroxy-1-piperidinecarboxylate

: 1429790-75-9
(±)-9-[(4-bromo-2,6-difluorophenyl)methyl]-4-cyclopropyl-1-oxa-4,9-diazaspiro[5.5]undecane-3,8-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran / 74 h / 0 °C

2.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; sodium hydroxide / tetrahydrofuran

3.1: hydrogenchloride / 1,4-dioxane; ethanol / 20 °C / Cooling with ice

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.08 h / 20 °C

4.2: 1 h / 80 °C

5.1: potassium permanganate; N-benzyl-N,N,N-triethylammonium chloride / dichloromethane / 20 °C

With hydrogenchloride; potassium permanganate; N-benzyl-N,N,N-triethylammonium chloride; tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 147804-30-6
1-oxa-6-aza-spiro-[2.5]octane-6-caboxylic acid tert-butyl ester

: 1429790-75-9
(±)-9-[(4-bromo-2,6-difluorophenyl)methyl]-4-cyclopropyl-1-oxa-4,9-diazaspiro[5.5]undecane-3,8-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / 20 h / 75 °C / Inert atmosphere; Sealed tube

2.1: sodium hydrogencarbonate / tetrahydrofuran / 74 h / 0 °C

3.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; sodium hydroxide / tetrahydrofuran

4.1: hydrogenchloride / 1,4-dioxane; ethanol / 20 °C / Cooling with ice

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.08 h / 20 °C

5.2: 1 h / 80 °C

6.1: potassium permanganate; N-benzyl-N,N,N-triethylammonium chloride / dichloromethane / 20 °C

With hydrogenchloride; potassium permanganate; N-benzyl-N,N,N-triethylammonium chloride; tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; acetonitrile;