methyl 3-{2-[2-(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

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Chemical Name:methyl 3-{2-[2-(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate
CAS No.:540526-73-6
Molecular Formula:C₄₉H₄₈ClNO₄Si
Molecular Weight:778.463
Hs Code.:

Synonyms:methyl 3-{2-[2-(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

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Chemical Property of methyl 3-{2-[2-(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

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Technology Process of methyl 3-{2-[2-(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

There total 9 articles about methyl 3-{2-[2-(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 540522-76-7
2-[2-(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethanol

: 19438-10-9
methyl 3-hydroxybenzoate

: 540526-73-6
methyl 3-{2-[2-(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; for 48h;
DOI:10.1021/jm061131z

Reference yield: 85.0%

: 540526-73-6
methyl 3-{2-[2-(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

Guidance literature:

Reference yield:

: 540522-73-4
4-chloro-N-(diphenylmethyl)-2-iodoaniline

: 540526-73-6
methyl 3-{2-[2-(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 92 percent / Et₃N; CuI / PdCl₂(PPh₃)2 / 19 h / 45 °C

2.1: CuI / dimethylformamide / 3.5 h / Heating

3.1: 14.2 g / imidazole / CH₂Cl₂ / 20 °C

4.1: CH₂Cl₂ / 3 h / 0 °C

4.2: Et₃N / CH₂Cl₂ / 0.67 h

5.1: 12.2 g / BH₃*Me₂S / tetrahydrofuran / 17 h / 80 °C

6.1: 85 percent / Ph₃P; DIAD / tetrahydrofuran / 48 h

With 1H-imidazole; copper(l) iodide; di-isopropyl azodicarboxylate; dimethylsulfide borane complex; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 6.1: Mitsunobu reaction;
DOI:10.1021/jm061131z