(1R,4R)-4-({[4-(2-cyclopentylethyl)phenyl]-[2-(2-naphthyl)ethyl]amino}carbonyl)-2,2-difluorocyclohexyl (2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Base Information

• Chemical Name: (1R,4R)-4-({[4-(2-cyclopentylethyl)phenyl]-[2-(2-naphthyl)ethyl]amino}carbonyl)-2,2-difluorocyclohexyl (2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
• CAS No.: 1246923-70-5
• Molecular Formula: C₄₂H₄₄F₅NO₄
• Molecular Weight: 721.808

Synonyms:(1R,4R)-4-({[4-(2-cyclopentylethyl)phenyl]-[2-(2-naphthyl)ethyl]amino}carbonyl)-2,2-difluorocyclohexyl (2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Chemical Property of (1R,4R)-4-({[4-(2-cyclopentylethyl)phenyl]-[2-(2-naphthyl)ethyl]amino}carbonyl)-2,2-difluorocyclohexyl (2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

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Technology Process of (1R,4R)-4-({[4-(2-cyclopentylethyl)phenyl]-[2-(2-naphthyl)ethyl]amino}carbonyl)-2,2-difluorocyclohexyl (2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

There total 1 articles about (1R,4R)-4-({[4-(2-cyclopentylethyl)phenyl]-[2-(2-naphthyl)ethyl]amino}carbonyl)-2,2-difluorocyclohexyl (2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

(1RS,4RS)-N-[4-(2-cyclopentylethyl)phenyl]-3,3-difluoro-4-hydroxy-N-[2-(2-naphthyl)ethyl]cyclohexanecarboxamide + (R)-methoxytrifluoromethylphenylacetyl chloride (20445-33-4,39637-99-5) → (1R,4R)-4-({[4-(2-cyclopentylethyl)phenyl]-[2-(2-naphthyl)ethyl]amino}carbonyl)-2,2-difluorocyclohexyl (2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate (1246923-70-5) + (1S,4S)-4-({[4-(2-cyclopentylethyl)phenyl]-[2-(2-naphthyl)ethyl]amino}carbonyl)-2,2-difluorocyclohexyl (2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate (1246923-69-2)

Guidance literature:

With dmap; In tetrahydrofuran; at 0 - 22 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201000712

Reference yield: 83.0%

(1R,4R)-4-({[4-(2-cyclopentylethyl)phenyl]-[2-(2-naphthyl)ethyl]amino}carbonyl)-2,2-difluorocyclohexyl (2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate (1246923-70-5) → (1R,4R)-N-[4-(2-cyclopentylethyl)phenyl]-3,3-difluoro-4-hydroxy-N-[2-(2-naphthyl)ethyl]cyclohexanecarboxamide (1246923-87-4)

Guidance literature:

With methanol; sodium methylate; In tetrahydrofuran; at 0 - 22 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201000712

upstream raw materials:

(R)-methoxytrifluoromethylphenylacetyl chloride

Downstream raw materials:

(1R,4R)-N-[4-(2-cyclopentylethyl)phenyl]-3,3-difluoro-4-hydroxy-N-[2-(2-naphthyl)ethyl]cyclohexanecarboxamide

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