(2R)-2-<(2-Bromo-4,5-dimethoxybenzoyl)methyl>-N-<(4-methoxyphenyl)acetyl>piperidine

Base Information

Chemical Name:(2R)-2-<(2-Bromo-4,5-dimethoxybenzoyl)methyl>-N-<(4-methoxyphenyl)acetyl>piperidine
CAS No.:167696-05-1
Molecular Formula:C₂₄H₂₈BrNO₅
Molecular Weight:490.394
Hs Code.:

Synonyms:(2R)-2-<(2-Bromo-4,5-dimethoxybenzoyl)methyl>-N-<(4-methoxyphenyl)acetyl>piperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-2-<(2-Bromo-4,5-dimethoxybenzoyl)methyl>-N-<(4-methoxyphenyl)acetyl>piperidine

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Technology Process of (2R)-2-<(2-Bromo-4,5-dimethoxybenzoyl)methyl>-N-<(4-methoxyphenyl)acetyl>piperidine

There total 11 articles about (2R)-2-<(2-Bromo-4,5-dimethoxybenzoyl)methyl>-N-<(4-methoxyphenyl)acetyl>piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: (2R)-2-<(2RS)-2-(2-Bromo-4,5-dimethoxyphenyl)-2-hydroxyethyl>-N-<(4-methoxyphenyl)acetyl>piperidine

: 167696-05-1
(2R)-2-<(2-Bromo-4,5-dimethoxybenzoyl)methyl>-N-<(4-methoxyphenyl)acetyl>piperidine

Guidance literature:: With dipyridinium dichromate; 4 A molecular sieve; In dichloromethane; Ambient temperature;
DOI:10.1016/0040-4039(94)02376-M

Reference yield:

: (6RS)-N-<(2S)-2-<(Benzyloxy)methyl>pyrrolidino>-6-hydroxy-2-piperidinone

: 167696-05-1
(2R)-2-<(2-Bromo-4,5-dimethoxybenzoyl)methyl>-N-<(4-methoxyphenyl)acetyl>piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / pyridinium p-toluenesulfonate / 3 h / Ambient temperature

2: 70 percent / BF₃*Et₂O / CH₂Cl₂ / 1 h / Ambient temperature

3: 1.) BH₃*THF, 2.) 5percent aq. NaOH / 1.) THF, room temp., 15 min; reflux, 24 h, 2.) CH₂Cl₂, 0 deg C, 30 min; room temp., 30 min

4: 77 percent / PDC, 4 Angstroem molecular sieves / CH₂Cl₂ / 5 h / Ambient temperature

With sodium hydroxide; dipyridinium dichromate; borane-THF; 4 A molecular sieve; boron trifluoride diethyl etherate; pyridinium p-toluenesulfonate; In dichloromethane;
DOI:10.1021/jo00124a025

Reference yield:

: (6RS)-N-<(2S)-2-<(Benzyloxy)methyl>pyrrolidino>-6-methoxy-2-piperidinone

: 167696-05-1
(2R)-2-<(2-Bromo-4,5-dimethoxybenzoyl)methyl>-N-<(4-methoxyphenyl)acetyl>piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / BF₃*Et₂O / CH₂Cl₂ / 1 h / Ambient temperature

2: 1.) BH₃*THF, 2.) 5percent aq. NaOH / 1.) THF, room temp., 15 min; reflux, 24 h, 2.) CH₂Cl₂, 0 deg C, 30 min; room temp., 30 min

3: 77 percent / PDC, 4 Angstroem molecular sieves / CH₂Cl₂ / 5 h / Ambient temperature

With sodium hydroxide; dipyridinium dichromate; borane-THF; 4 A molecular sieve; boron trifluoride diethyl etherate; In dichloromethane;
DOI:10.1021/jo00124a025