Chemical Property of Fluprednisolone
Chemical Property:
- Vapor Pressure:1.77E-15mmHg at 25°C
- Melting Point:208-213°
- Refractive Index:1.597
- Boiling Point:572.3 °C at 760 mmHg
- Flash Point:299.9 °C
- PSA：94.83000
- Density:1.35 g/cm3
- LogP:1.50560
- Storage Temp.:Refrigerator
- Solubility.:Dioxane (Slightly), DMSO (Slightly), Methanol (Slightly)
- Water Solubility.:174.2mg/L(20 oC)
- XLogP3:1.4
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:2
- Exact Mass:378.18425212
- Heavy Atom Count:27
- Complexity:760
- Purity/Quality:
-
99% *data from raw suppliers
6α-Fluprednisolone *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC12CC(C3C(C1CCC2(C(=O)CO)O)CC(C4=CC(=O)C=CC34C)F)O
- Isomeric SMILES:C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)C[C@@H](C4=CC(=O)C=C[C@]34C)F)O
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Description
Fluprednisolone (6α-fluoro-11β,17,21-trihydroxy-pregna-1,4-diene-3,20-dione) is the 16-desmethyl analogue of
paramethasone. Its activity is similar to that of paramethasone, and it has approximately 2.5 times the
antirheumatic potency of prednisolone. With doses of 2 to 7 mg, evidence of salt and water retention has not
been noted. The therapeutic index, however, probably is the same or only a little greater than that for
prednisolone. Because no new adverse reactions have been noted during the administration of this drug on a
short-term basis, it seems that a 6α-fluoro group does not deleteriously affect the activity of prednisolone
(49,75).
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Uses
6α-Fluprednisolone is an anti-inflammatory corticosteroid metabolite. Glucocorticoid.
