(S)-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)(3-(hydroxymethyl)-3,4- dihydroisoquinolin-2(1H)-yl)methanone

Base Information

Chemical Name:(S)-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)(3-(hydroxymethyl)-3,4- dihydroisoquinolin-2(1H)-yl)methanone
CAS No.:762245-27-2
Molecular Formula:C₂₅H₂₄N₂O₆
Molecular Weight:448.475
Hs Code.:

Synonyms:(S)-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)(3-(hydroxymethyl)-3,4- dihydroisoquinolin-2(1H)-yl)methanone

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Chemical Property of (S)-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)(3-(hydroxymethyl)-3,4- dihydroisoquinolin-2(1H)-yl)methanone

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Technology Process of (S)-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)(3-(hydroxymethyl)-3,4- dihydroisoquinolin-2(1H)-yl)methanone

There total 14 articles about (S)-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)(3-(hydroxymethyl)-3,4- dihydroisoquinolin-2(1H)-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 18881-17-9,62855-02-1,62928-94-3,63006-93-9
(S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline

: 64154-78-5
4-benzyloxy-5-methoxy-2-nitrobenzoyl chloride

: 762245-27-2
(S)-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)(3-(hydroxymethyl)-3,4- dihydroisoquinolin-2(1H)-yl)methanone

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 25 ℃; Inert atmosphere;

Reference yield:

: 18881-17-9,62855-02-1,62928-94-3,63006-93-9
(S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline

: 60547-92-4
4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid

: 762245-27-2
(S)-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)(3-(hydroxymethyl)-3,4- dihydroisoquinolin-2(1H)-yl)methanone

Guidance literature:: 4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 22 ℃; for 0.25h;

(S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline; In dichloromethane; at 22 ℃; for 2h; Inert atmosphere;

Reference yield:

: 60547-92-4
4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid

: 762245-27-2
(S)-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)(3-(hydroxymethyl)-3,4- dihydroisoquinolin-2(1H)-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 20 °C

2: triethylamine / dichloromethane / 2 h / -10 - 20 °C

3: lithium borohydride / tetrahydrofuran / 3 h / 0 - 20 °C

With lithium borohydride; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;