(1S,2R)-2-((R)-1-Hydroxy-prop-2-ynyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide

Base Information

Chemical Name:(1S,2R)-2-((R)-1-Hydroxy-prop-2-ynyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide
CAS No.:213018-77-0
Molecular Formula:C₁₇H₂₁NO₂
Molecular Weight:271.359
Hs Code.:

Synonyms:(1S,2R)-2-((R)-1-Hydroxy-prop-2-ynyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide

Suppliers and Price of (1S,2R)-2-((R)-1-Hydroxy-prop-2-ynyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2R)-2-((R)-1-Hydroxy-prop-2-ynyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide

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Technology Process of (1S,2R)-2-((R)-1-Hydroxy-prop-2-ynyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide

There total 1 articles about (1S,2R)-2-((R)-1-Hydroxy-prop-2-ynyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 172016-00-1
(1S,2R)-2-Formyl-1-phenyl-cyclopropanecarboxylic acid diethylamide

: 4301-14-8
acetylenemagnesium bromide

: 213018-77-0
(1S,2R)-2-((R)-1-Hydroxy-prop-2-ynyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide

Guidance literature:: In tetrahydrofuran; at -10 ℃; for 3h;
DOI:10.1021/jm980238m

Reference yield: 89.0%

: 213018-77-0
(1S,2R)-2-((R)-1-Hydroxy-prop-2-ynyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide

: 171889-14-8
(1S,2R)-2-((S)-1-Hydroxy-propyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 2h; under 760 Torr; Ambient temperature;
DOI:10.1021/jm980238m

Reference yield:

: 213018-77-0
(1S,2R)-2-((R)-1-Hydroxy-prop-2-ynyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide

: 172015-90-6
(1S,2R)-2-((R)-1-Amino-propyl)-1-phenyl-cyclopropanecarboxylic acid diethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Co₂(CO)8, 2.) TFA, 3.) NaN₃, 4.) CAN

2: 1.) Ph₃P, pyridine, 2.) 28percent aq. NH₄OH / 1.) RT, 30 min, 2.) RT, 36 h

3: 98 percent / H₂ / 10percent Pd/C / methanol / 2 h / 760 Torr / Ambient temperature

With pyridine; ammonium hydroxide; sodium azide; dicobalt octacarbonyl; ammonium cerium(IV) nitrate; hydrogen; triphenylphosphine; trifluoroacetic acid; palladium on activated charcoal; In methanol;
DOI:10.1021/jm980238m