(S)-N'-(6-chloropyridazin-3-yl)-4-(5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)benzohydrazide

Base Information

• Chemical Name: (S)-N'-(6-chloropyridazin-3-yl)-4-(5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)benzohydrazide
• CAS No.: 1456507-42-8
• Molecular Formula: C₂₂H₂₀ClN₅O₃
• Molecular Weight: 437.885
• Mol file: 1456507-42-8.mol

Synonyms:(S)-N'-(6-chloropyridazin-3-yl)-4-(5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)benzohydrazide

Chemical Property of (S)-N'-(6-chloropyridazin-3-yl)-4-(5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)benzohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N'-(6-chloropyridazin-3-yl)-4-(5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)benzohydrazide

There total 4 articles about (S)-N'-(6-chloropyridazin-3-yl)-4-(5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)benzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Chloro-6-hydrazinopyridazine (17284-97-8) + (S)-4-(5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)benzoic acid (1437790-03-8) → (S)-N'-(6-chloropyridazin-3-yl)-4-(5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)benzohydrazide (1456507-42-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 55 ℃; Sealed tube;

Reference yield:

methyl 4-iodobenzoate (619-44-3) → (S)-N'-(6-chloropyridazin-3-yl)-4-(5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)benzohydrazide (1456507-42-8)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium phosphate; N,N`-dimethylethylenediamine; copper(l) iodide / 1,4-dioxane / Reflux; Inert atmosphere

2: water; lithium hydroxide / methanol; tetrahydrofuran / 50 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 55 °C / Sealed tube

With potassium phosphate; copper(l) iodide; water; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; N,N`-dimethylethylenediamine; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

(S)-methyl 4-(5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)benzoate (1437789-68-8) → (S)-N'-(6-chloropyridazin-3-yl)-4-(5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)benzohydrazide (1456507-42-8)

Guidance literature:

Multi-step reaction with 2 steps

1: water; lithium hydroxide / methanol; tetrahydrofuran / 50 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 55 °C / Sealed tube

With water; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

upstream raw materials:

methyl 4-iodobenzoate

(S)-methyl 4-(5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)benzoate

3-Chloro-6-hydrazinopyridazine

(S)-4-(5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)benzoic acid

Downstream raw materials:

(S)-3-(4-(6-chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)phenyl)-5,5-dimethyl-4-phenyloxazolidin-2-one