4-(2-chloro-4-fluorophenyl)-5-[(2,4-difluorophenyl)methyl]-1,3-dimethyl-1H-pyrazole

Base Information

Chemical Name:4-(2-chloro-4-fluorophenyl)-5-[(2,4-difluorophenyl)methyl]-1,3-dimethyl-1H-pyrazole
CAS No.:1193355-52-0
Molecular Formula:C₁₈H₁₄ClF₃N₂
Molecular Weight:350.771
Hs Code.:

Synonyms:4-(2-chloro-4-fluorophenyl)-5-[(2,4-difluorophenyl)methyl]-1,3-dimethyl-1H-pyrazole

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Chemical Property of 4-(2-chloro-4-fluorophenyl)-5-[(2,4-difluorophenyl)methyl]-1,3-dimethyl-1H-pyrazole

Chemical Property:

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Technology Process of 4-(2-chloro-4-fluorophenyl)-5-[(2,4-difluorophenyl)methyl]-1,3-dimethyl-1H-pyrazole

There total 3 articles about 4-(2-chloro-4-fluorophenyl)-5-[(2,4-difluorophenyl)methyl]-1,3-dimethyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 312692-88-9
(2,4-difluorobenzyl)zinc (II) chloride

: 1193511-97-5
5-bromo-4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazole

: 1193355-52-0
4-(2-chloro-4-fluorophenyl)-5-[(2,4-difluorophenyl)methyl]-1,3-dimethyl-1H-pyrazole

Guidance literature:: bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; for 3h; Reflux;

Reference yield:

: 1193511-96-4
4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine

: 1193355-52-0
4-(2-chloro-4-fluorophenyl)-5-[(2,4-difluorophenyl)methyl]-1,3-dimethyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 0 - 20 °C

2: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 3 h / Reflux

With tert.-butylnitrite; copper(ll) bromide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; acetonitrile;

Reference yield:

: 75279-56-0
2-(2-chloro-4-fluorophenyl)acetonitrile

: 1193355-52-0
4-(2-chloro-4-fluorophenyl)-5-[(2,4-difluorophenyl)methyl]-1,3-dimethyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; xylenes / 0.25 h / 50 °C / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 0 - 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 3 h / Reflux

With tert.-butylnitrite; sodium hydride; copper(ll) bromide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; acetonitrile; mineral oil; xylenes;