(E)-3-(4-((2-methoxyethoxy)methoxy)-3,5-dimethylstyryl)-4-methyl-2H-chromen-2-one

Base Information

Chemical Name:(E)-3-(4-((2-methoxyethoxy)methoxy)-3,5-dimethylstyryl)-4-methyl-2H-chromen-2-one
CAS No.:1456809-39-4
Molecular Formula:C₂₄H₂₆O₅
Molecular Weight:394.467
Hs Code.:

Synonyms:(E)-3-(4-((2-methoxyethoxy)methoxy)-3,5-dimethylstyryl)-4-methyl-2H-chromen-2-one

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Chemical Property of (E)-3-(4-((2-methoxyethoxy)methoxy)-3,5-dimethylstyryl)-4-methyl-2H-chromen-2-one

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Technology Process of (E)-3-(4-((2-methoxyethoxy)methoxy)-3,5-dimethylstyryl)-4-methyl-2H-chromen-2-one

There total 4 articles about (E)-3-(4-((2-methoxyethoxy)methoxy)-3,5-dimethylstyryl)-4-methyl-2H-chromen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 50361-81-4
3-bromo-4-hydroxycoumarin

: 1456809-36-1
2-((2-methoxyethoxy)methoxy)-1,3-dimethyl-5-vinylbenzene

: 1456809-39-4
(E)-3-(4-((2-methoxyethoxy)methoxy)-3,5-dimethylstyryl)-4-methyl-2H-chromen-2-one

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triethylamine; tert-butyl XPhos; at 70 ℃; for 10h; Inert atmosphere;
DOI:10.1039/c3cc44667k

Reference yield:

: 2374-05-2
4-bromo-2,6-dimethyl-phenol

: 1456809-39-4
(E)-3-(4-((2-methoxyethoxy)methoxy)-3,5-dimethylstyryl)-4-methyl-2H-chromen-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 10 h / Inert atmosphere; Reflux

3: triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / 10 h / 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; triethylamine; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; 3: |Heck Reaction;
DOI:10.1039/c3cc44667k

Reference yield:

: 607-71-6
4-methyl-2H-chromen-2-one

: 1456809-39-4
(E)-3-(4-((2-methoxyethoxy)methoxy)-3,5-dimethylstyryl)-4-methyl-2H-chromen-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; ammonium acetate / acetonitrile / 48 h / 0 - 20 °C / Inert atmosphere

2: triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / 10 h / 70 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; ammonium acetate; triethylamine; tert-butyl XPhos; In acetonitrile; 2: |Heck Reaction;
DOI:10.1039/c3cc44667k