Technology Process of N-(6-(1H-1,2,4-triazol-1-yl)pyridin-3-yl)-6-(3-ethylureido)-4-(phenylamino)nicotinamide
There total 6 articles about N-(6-(1H-1,2,4-triazol-1-yl)pyridin-3-yl)-6-(3-ethylureido)-4-(phenylamino)nicotinamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-(3-ethylureido)-4-(phenylamino)nicotinic acid;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.25h;
6-(1H-1,2,4-triazol-1-yl)pyridin-3-amine;
In
N,N-dimethyl-formamide;
at 50 ℃;
for 24h;
DOI:10.1016/j.ejmech.2014.08.025
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: acetic acid / 2 h / 120 °C / Inert atmosphere
1.2: 18 h / 0 - 20 °C / Inert atmosphere
2.1: trichlorophosphate / 2.5 h / 110 °C
3.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium tert-butylate / water; 1,4-dioxane / 16 h / 20 - 100 °C / Inert atmosphere
4.1: hydrogenchloride / ethanol; water / 16 h / 60 °C
5.1: sodium hydroxide / water / 48 h / 75 °C
6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 20 °C
6.2: 24 h / 50 °C
With
hydrogenchloride; potassium tert-butylate; palladium diacetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide; trichlorophosphate;
In
1,4-dioxane; ethanol; water; acetic acid; N,N-dimethyl-formamide;
3.1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.ejmech.2014.08.025
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: trichlorophosphate / 2.5 h / 110 °C
2.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium tert-butylate / water; 1,4-dioxane / 16 h / 20 - 100 °C / Inert atmosphere
3.1: hydrogenchloride / ethanol; water / 16 h / 60 °C
4.1: sodium hydroxide / water / 48 h / 75 °C
5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 20 °C
5.2: 24 h / 50 °C
With
hydrogenchloride; potassium tert-butylate; palladium diacetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide; trichlorophosphate;
In
1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;
2.1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.ejmech.2014.08.025
