Vigabatrin

Base Information

Chemical Name:Vigabatrin
CAS No.:68506-86-5
Deprecated CAS:60643-86-9
Molecular Formula:C6H11NO2
Molecular Weight:129.16
Hs Code.:2922498050
European Community (EC) Number:270-929-6,637-414-1
UNII:GR120KRT6K
DSSTox Substance ID:DTXSID4041153
Nikkaji Number:J82.341D
Wikipedia:Vigabatrin
Wikidata:Q421663
NCI Thesaurus Code:C87611
RXCUI:14851
Pharos Ligand ID:12RKXBK1T2AJ
Metabolomics Workbench ID:43313
ChEMBL ID:CHEMBL89598
Mol file:68506-86-5.mol

Synonyms:gamma Vinyl GABA;gamma Vinyl gamma Aminobutyric Acid;gamma-Vinyl-GABA;gamma-Vinyl-gamma-Aminobutyric Acid;Sabril;Sabrilex;Vigabatrin

Suppliers and Price of Vigabatrin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
(±)-Vigabatrin
50mg
$ 385.00

Sigma-Aldrich
Vigabatrin United States Pharmacopeia (USP) Reference Standard
200mg
$ 523.00

Sigma-Aldrich
Vigabatrin UnitedStatesPharmacopeia(USP)ReferenceStandard
100 mg
$ 503.00

Sigma-Aldrich
(±)-Vigabatrin
10mg
$ 94.10

Sigma-Aldrich
Vigabatrin European Pharmacopoeia (EP) Reference Standard
y0001400
$ 190.00

DC Chemicals
Vigabatrin >98%
100 mg
$ 300.00

DC Chemicals
Vigabatrin >98%
250 mg
$ 600.00

ChemScene
Vigabatrin >98.0%
50mg
$ 320.00

ChemScene
Vigabatrin >98.0%
10mg
$ 80.00

Cayman Chemical
Vigabatrin ≥95%
10mg
$ 74.00

Total 17 raw suppliers

Chemical Property of Vigabatrin

Chemical Property:

Melting Point:209℃
Boiling Point:277.7±28.0 °C(Predicted)
PKA:4.36±0.10(Predicted)
PSA：63.32000
Density:1.064±0.06 g/cm3(Predicted)
LogP:1.06480
Storage Temp.:2-8°C
Solubility.:Methanol (Slightly), Water (Slightly)
XLogP3:-2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:129.078978594
Heavy Atom Count:9
Complexity:112

Purity/Quality:

97% ^*data from raw suppliers

(±)-Vigabatrin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Anticonvulsants
Canonical SMILES:C=CC(CCC(=O)O)N
Recent ClinicalTrials:Preventing Epilepsy Using Vigabatrin In Infants With Tuberous Sclerosis Complex
Recent EU Clinical Trials:A Phase 3, Randomized, Open-Label Study to Evaluate the Efficacy and Safety of AMZ002, Compared to Vigabatrin, in the Treatment of Infantile Spasms
Recent NIPH Clinical Trials:A open-label study of M071754 in patients with infantile spasms
Uses rac-Vigabatrin a novel antiepileptic drug. Antidepressant; antipsychotic; anxiolytic.

Technology Process of Vigabatrin

There total 94 articles about Vigabatrin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 60643-86-9,68506-86-5
4-amino-5-hexenoic acid

Guidance literature:

Reference yield: 94.0%

: 1099752-69-8
methyl (-)-(4S)-4-[bis(tert-butoxycarbonyl)amino]hex-5-enoate

: 74046-07-4,68506-86-5
(+)-Vigabatrin

Guidance literature:: With hydrogenchloride; acetic acid; In water; at 60 ℃; for 12h;
DOI:10.1055/s-0028-1083158

Reference yield: 74.0%

: 7529-16-0
5(S)-Vinyl-2-Pyrrolidinone

: 60643-86-9,68506-86-5
4-amino-5-hexenoic acid

Guidance literature:: 5(S)-Vinyl-2-Pyrrolidinone; With potassium hydroxide; In water; for 2h; Reflux;

With acetic acid; In water; isopropyl alcohol; at 0 - 30 ℃; for 4.5h;
DOI:10.1007/s11696-019-01030-2