5-amino-6-(2-hydroxyphenyl)-2-methyl-1,2-dihydropyrazolo[3,4-b]pyridin-3-one

Base Information

Chemical Name:5-amino-6-(2-hydroxyphenyl)-2-methyl-1,2-dihydropyrazolo[3,4-b]pyridin-3-one
CAS No.:1363156-88-0
Molecular Formula:C₁₃H₁₂N₄O₂
Molecular Weight:256.264
Hs Code.:

Synonyms:5-amino-6-(2-hydroxyphenyl)-2-methyl-1,2-dihydropyrazolo[3,4-b]pyridin-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-amino-6-(2-hydroxyphenyl)-2-methyl-1,2-dihydropyrazolo[3,4-b]pyridin-3-one

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Technology Process of 5-amino-6-(2-hydroxyphenyl)-2-methyl-1,2-dihydropyrazolo[3,4-b]pyridin-3-one

There total 4 articles about 5-amino-6-(2-hydroxyphenyl)-2-methyl-1,2-dihydropyrazolo[3,4-b]pyridin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1363156-69-7
6-(2-hydroxyphenyl)-2-methyl-5-nitro-1,2-dihydropyrazolo[3,4-b]pyridin-3-one

: 1363156-88-0
5-amino-6-(2-hydroxyphenyl)-2-methyl-1,2-dihydropyrazolo[3,4-b]pyridin-3-one

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 48h; under 760.051 Torr;
DOI:10.1016/j.tet.2011.06.101

Reference yield:

: 59507-92-5
3-nitro-4H-chromen-4-one

: 1363156-88-0
5-amino-6-(2-hydroxyphenyl)-2-methyl-1,2-dihydropyrazolo[3,4-b]pyridin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / 2 h / Reflux; Inert atmosphere

2: palladium on activated charcoal; hydrogen / methanol / 48 h / 20 °C / 760.05 Torr

With palladium on activated charcoal; hydrogen; acetic acid; In methanol;
DOI:10.1016/j.tet.2011.06.101

Reference yield:

: 1076-38-6,92395-12-5
4-hydroxy[1]benzopyran-2-one

: 1363156-88-0
5-amino-6-(2-hydroxyphenyl)-2-methyl-1,2-dihydropyrazolo[3,4-b]pyridin-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: nitric acid; acetic acid; sodium nitrite / 0.25 h / 60 °C

2: water; sodium hydroxide / 3 h / 60 °C

3: sulfuric acid / 6 h / Reflux

4: acetic acid / 2 h / Reflux; Inert atmosphere

5: palladium on activated charcoal; hydrogen / methanol / 48 h / 20 °C / 760.05 Torr

With sulfuric acid; palladium on activated charcoal; water; hydrogen; nitric acid; acetic acid; sodium hydroxide; sodium nitrite; In methanol;
DOI:10.1016/j.tet.2011.06.101