(4aR,6R,7S,8aR,9aS,10aS)-6-Benzyloxy-7-(2-benzyloxy-ethyl)-4,4a,7,10a-tetramethyl-4a,5,6,7,8a,9,9a,10a-octahydro-1,8,10-trioxa-anthracen-2-one

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Chemical Name:(4aR,6R,7S,8aR,9aS,10aS)-6-Benzyloxy-7-(2-benzyloxy-ethyl)-4,4a,7,10a-tetramethyl-4a,5,6,7,8a,9,9a,10a-octahydro-1,8,10-trioxa-anthracen-2-one
CAS No.:159327-94-3
Molecular Formula:C₃₁H₃₈O₆
Molecular Weight:506.639
Hs Code.:

Synonyms:(4aR,6R,7S,8aR,9aS,10aS)-6-Benzyloxy-7-(2-benzyloxy-ethyl)-4,4a,7,10a-tetramethyl-4a,5,6,7,8a,9,9a,10a-octahydro-1,8,10-trioxa-anthracen-2-one

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Chemical Property of (4aR,6R,7S,8aR,9aS,10aS)-6-Benzyloxy-7-(2-benzyloxy-ethyl)-4,4a,7,10a-tetramethyl-4a,5,6,7,8a,9,9a,10a-octahydro-1,8,10-trioxa-anthracen-2-one

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Technology Process of (4aR,6R,7S,8aR,9aS,10aS)-6-Benzyloxy-7-(2-benzyloxy-ethyl)-4,4a,7,10a-tetramethyl-4a,5,6,7,8a,9,9a,10a-octahydro-1,8,10-trioxa-anthracen-2-one

There total 6 articles about (4aR,6R,7S,8aR,9aS,10aS)-6-Benzyloxy-7-(2-benzyloxy-ethyl)-4,4a,7,10a-tetramethyl-4a,5,6,7,8a,9,9a,10a-octahydro-1,8,10-trioxa-anthracen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 159327-93-2
(Dimethoxy-phosphoryl)-acetic acid (2S,3S,4aR,6S,7R,8aS)-2-acetyl-7-benzyloxy-6-(2-benzyloxy-ethyl)-2,6,8a-trimethyl-octahydro-pyrano[3,2-b]pyran-3-yl ester

: 159327-94-3
(4aR,6R,7S,8aR,9aS,10aS)-6-Benzyloxy-7-(2-benzyloxy-ethyl)-4,4a,7,10a-tetramethyl-4a,5,6,7,8a,9,9a,10a-octahydro-1,8,10-trioxa-anthracen-2-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; lithium chloride; In acetonitrile; at 25 ℃; for 3h;
DOI:10.1021/ja00099a081

Reference yield:

: 131311-17-6
[(2R,3S,4aR,6S,7R,8aS)-7-Benzyloxy-6-(2-benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-2,6,8a-trimethyl-octahydro-pyrano[3,2-b]pyran-2-yl]-methanol

: 159327-94-3
(4aR,6R,7S,8aR,9aS,10aS)-6-Benzyloxy-7-(2-benzyloxy-ethyl)-4,4a,7,10a-tetramethyl-4a,5,6,7,8a,9,9a,10a-octahydro-1,8,10-trioxa-anthracen-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CHCl₂, -78 deg C, 2.) CH₂Cl₂, 1 h

2: 96 percent / tetrahydrofuran / 1 h / 0 °C

3: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CHCl₂, -78 deg C, 2.) CH₂Cl₂, 1 h

4: 100 percent / TBAF / tetrahydrofuran / 2 h / 25 °C

5: 82 percent / pyridine / CH₂Cl₂ / 5 h / 0 °C

6: 90 percent / neat (no solvent) / 3 h / 180 °C

7: 88 percent / i-Pr₂NEt, LiCl / acetonitrile / 3 h / 25 °C

With pyridine; oxalyl dichloride; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/ja00099a081

Reference yield:

: 131311-18-7
(2S,3S,4aR,6S,7R,8aS)-7-Benzyloxy-6-(2-benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-2,6,8a-trimethyl-octahydro-pyrano[3,2-b]pyran-2-carbaldehyde

: 159327-94-3
(4aR,6R,7S,8aR,9aS,10aS)-6-Benzyloxy-7-(2-benzyloxy-ethyl)-4,4a,7,10a-tetramethyl-4a,5,6,7,8a,9,9a,10a-octahydro-1,8,10-trioxa-anthracen-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / tetrahydrofuran / 1 h / 0 °C

2: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CHCl₂, -78 deg C, 2.) CH₂Cl₂, 1 h

3: 100 percent / TBAF / tetrahydrofuran / 2 h / 25 °C

4: 82 percent / pyridine / CH₂Cl₂ / 5 h / 0 °C

5: 90 percent / neat (no solvent) / 3 h / 180 °C

6: 88 percent / i-Pr₂NEt, LiCl / acetonitrile / 3 h / 25 °C

With pyridine; oxalyl dichloride; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/ja00099a081