ethyl 3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-benzyloxyphenoxy)propoxy)-6-(4-cyanobutyloxy)phenyl)-propionate

Base Information

Chemical Name:ethyl 3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-benzyloxyphenoxy)propoxy)-6-(4-cyanobutyloxy)phenyl)-propionate
CAS No.:152608-89-4
Molecular Formula:C₄₀H₄₄FNO₆
Molecular Weight:653.791
Hs Code.:

Synonyms:ethyl 3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-benzyloxyphenoxy)propoxy)-6-(4-cyanobutyloxy)phenyl)-propionate

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Chemical Property of ethyl 3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-benzyloxyphenoxy)propoxy)-6-(4-cyanobutyloxy)phenyl)-propionate

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Technology Process of ethyl 3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-benzyloxyphenoxy)propoxy)-6-(4-cyanobutyloxy)phenyl)-propionate

There total 10 articles about ethyl 3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-benzyloxyphenoxy)propoxy)-6-(4-cyanobutyloxy)phenyl)-propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 152120-07-5
2-benzyloxy-1-(4-fluorophenyl)-5-ethyl-4-(3-chloro-1-propyloxy)benzene

: 152608-81-6
3-<6-<(4-cyanobutyl)oxy>-2-hydroxyphenyl>propanoic acid ethyl ester

: 152608-89-4
ethyl 3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-benzyloxyphenoxy)propoxy)-6-(4-cyanobutyloxy)phenyl)-propionate

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 90 ℃; for 24h;
DOI:10.1021/jm00022a006

Reference yield:

: 29682-12-0
1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone

: 152608-89-4
ethyl 3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-benzyloxyphenoxy)propoxy)-6-(4-cyanobutyloxy)phenyl)-propionate

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / K₂CO₃ / dimethylsulfoxide; butan-2-one / 24 h / Heating

2: 69 percent / trifluoroacetic acid, triethylsilane / CCl₄ / 1.5 h / Ambient temperature

3: 73 percent / N-bromosuccinimide / CCl₄ / 6 h / Ambient temperature

4: 84 percent / Pd(PPh₃)4, aq. Na₂CO₃ / ethanol; benzene / 16 h / Heating

5: 52 percent / K₂CO₃, KI / dimethylformamide / 24 h / 90 °C

With triethylsilane; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; trifluoroacetic acid; potassium iodide; In tetrachloromethane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; butanone; benzene;
DOI:10.1021/jm00022a006

Reference yield:

: 5414-21-1
5-bromopentan-1-nitrile

: 152608-89-4
ethyl 3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-benzyloxyphenoxy)propoxy)-6-(4-cyanobutyloxy)phenyl)-propionate

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / K₂CO₃ / dimethylformamide / 24 h / Ambient temperature

2: pivalic acid / toluene / 16 h / Heating

3: aq. HCl / tetrahydrofuran / 1 h / Ambient temperature

4: 52 percent / K₂CO₃, KI / dimethylformamide / 24 h / 90 °C

With hydrogenchloride; potassium carbonate; potassium iodide; Trimethylacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00022a006