Technology Process of N-[1-(7-methoxy-2,2-dimethyl-2H-chromen-6-yl)ethyl]benzamide
There total 7 articles about N-[1-(7-methoxy-2,2-dimethyl-2H-chromen-6-yl)ethyl]benzamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
benzoic acid;
With
1,1'-carbonyldiimidazole;
In
tetrahydrofuran;
at 20 ℃;
for 0.166667h;
Inert atmosphere;
C14H19NO2;
In
tetrahydrofuran;
at 20 ℃;
for 4h;
Inert atmosphere;
DOI:10.1021/jm401007p
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: formic acid / 100 °C
2.1: aluminum (III) chloride / dichloromethane / 0 °C
3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 110 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
5.1: ammonium acetate; sodium cyanoborohydride / methanol / 12 h / 20 °C / Inert atmosphere
6.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere
6.2: 4 h / 20 °C / Inert atmosphere
With
aluminum (III) chloride; formic acid; ammonium acetate; sodium cyanoborohydride; potassium carbonate; 1,1'-carbonyldiimidazole; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm401007p
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 110 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
3.1: ammonium acetate; sodium cyanoborohydride / methanol / 12 h / 20 °C / Inert atmosphere
4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere
4.2: 4 h / 20 °C / Inert atmosphere
With
ammonium acetate; sodium cyanoborohydride; potassium carbonate; 1,1'-carbonyldiimidazole; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm401007p
