N-<2-methoxy-6-(methylsulfonyl)phenyl>-N'-pentylurea

Base Information

• Chemical Name: N-<2-methoxy-6-(methylsulfonyl)phenyl>-N'-pentylurea
• CAS No.: 148726-72-1
• Molecular Formula: C₁₄H₂₂N₂O₄S
• Molecular Weight: 314.406
• Mol file: 148726-72-1.mol

Synonyms:N-<2-methoxy-6-(methylsulfonyl)phenyl>-N'-pentylurea

Chemical Property of N-<2-methoxy-6-(methylsulfonyl)phenyl>-N'-pentylurea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<2-methoxy-6-(methylsulfonyl)phenyl>-N'-pentylurea

There total 8 articles about N-<2-methoxy-6-(methylsulfonyl)phenyl>-N'-pentylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methoxy-2-nitrobenzoic acid (4920-80-3) → N-<2-methoxy-6-(methylsulfonyl)phenyl>-N'-pentylurea (148726-72-1)

Guidance literature:

Multi-step reaction with 8 steps

1: SOCl₂

2: 1.) NaN₃, 2.) H₂O, 4.) NaOH, 5.) HCl

3: 1.) 98percent sulfuric acid, NaNO₂, 2.) CuCl₂, 36percent aq. HCl / 1.) acetic acid, 10 deg C, 1 h, 2.) acetic acid, RT, 1 h

4: 35 percent / dimethylformamide; H₂O / 2 h / 100 °C

5: 61 percent / mcpba / CH₂Cl₂ / Ambient temperature

6: 99 percent / H₂ / 10percent Pd/C / ethyl acetate / 1 h / 760 Torr

7: pyridine / 2 h / 60 °C

8: toluene / 1 h / Heating

With pyridine; hydrogenchloride; sodium hydroxide; thionyl chloride; sodium azide; sulfuric acid; water; hydrogen; 3-chloro-benzenecarboperoxoic acid; copper dichloride; sodium nitrite; palladium on activated charcoal; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm00063a014

Reference yield:

3-chloro-2-nitroanisole (5472-99-1) → N-<2-methoxy-6-(methylsulfonyl)phenyl>-N'-pentylurea (148726-72-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 35 percent / dimethylformamide; H₂O / 2 h / 100 °C

2: 61 percent / mcpba / CH₂Cl₂ / Ambient temperature

3: 99 percent / H₂ / 10percent Pd/C / ethyl acetate / 1 h / 760 Torr

4: pyridine / 2 h / 60 °C

5: toluene / 1 h / Heating

With pyridine; hydrogen; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm00063a014

Reference yield:

3-methoxy-2-nitroaniline (16554-47-5) → N-<2-methoxy-6-(methylsulfonyl)phenyl>-N'-pentylurea (148726-72-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) 98percent sulfuric acid, NaNO₂, 2.) CuCl₂, 36percent aq. HCl / 1.) acetic acid, 10 deg C, 1 h, 2.) acetic acid, RT, 1 h

2: 35 percent / dimethylformamide; H₂O / 2 h / 100 °C

3: 61 percent / mcpba / CH₂Cl₂ / Ambient temperature

4: 99 percent / H₂ / 10percent Pd/C / ethyl acetate / 1 h / 760 Torr

5: pyridine / 2 h / 60 °C

6: toluene / 1 h / Heating

With pyridine; hydrogenchloride; sulfuric acid; hydrogen; 3-chloro-benzenecarboperoxoic acid; copper dichloride; sodium nitrite; palladium on activated charcoal; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm00063a014

upstream raw materials:

n-Pentylamine

3-methoxy-2-nitrobenzoic acid

3-chloro-2-nitroanisole

3-methoxy-2-nitroaniline

Downstream raw materials:

2-(N'-pentylureido)-3-(methylsulfonyl)phenol

Refernces