2--4-<(tert-butyldiphenylsilyl)oxy>-1-(tetrahydropyranyl)-1,4-butanediol

Base Information

Chemical Name:2--4-<(tert-butyldiphenylsilyl)oxy>-1-(tetrahydropyranyl)-1,4-butanediol
CAS No.:166194-05-4
Molecular Formula:C₃₂H₄₃NO₅SSi
Molecular Weight:581.849
Hs Code.:

2-<N-(tolylsulfonyl)amino>-4-<(tert-butyldiphenylsilyl)oxy>-1-(tetrahydropyranyl)-1,4-butanediol

Synonyms:2--4-<(tert-butyldiphenylsilyl)oxy>-1-(tetrahydropyranyl)-1,4-butanediol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2--4-<(tert-butyldiphenylsilyl)oxy>-1-(tetrahydropyranyl)-1,4-butanediol

Chemical Property:

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Technology Process of 2--4-<(tert-butyldiphenylsilyl)oxy>-1-(tetrahydropyranyl)-1,4-butanediol

There total 2 articles about 2--4-<(tert-butyldiphenylsilyl)oxy>-1-(tetrahydropyranyl)-1,4-butanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 166193-86-8
2--4-<(tert-butyldiphenylsilyl)oxy>-1,4-butanediol

: 166194-05-4
2--4-<(tert-butyldiphenylsilyl)oxy>-1-(tetrahydropyranyl)-1,4-butanediol

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1021/jm00014a023

Reference yield:

: 166193-85-7
2-<2-<(tert-butyldiphenylsilyl)oxy>ethyl>-2-oxazolidinone

: 166194-05-4
2--4-<(tert-butyldiphenylsilyl)oxy>-1-(tetrahydropyranyl)-1,4-butanediol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) KH, 18-crown-6 / 1.) THF, RT, 30 min, 2.) THF, RT, overnight

2: 82 percent / TsOH / CH₂Cl₂ / 2 h / 0 - 20 °C

With 18-crown-6 ether; potassium hydride; toluene-4-sulfonic acid; In dichloromethane;
DOI:10.1021/jm00014a023

Reference yield:

: 166194-05-4
2--4-<(tert-butyldiphenylsilyl)oxy>-1-(tetrahydropyranyl)-1,4-butanediol

: 2-butyl>amino>-4-<<(tert-butyldiphenylsilyl)oxy>butyl>phenylsulfone

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) KH, 2.) 18-crown-6 / 1.) THF, 2.) THF, a) RT, overnight, b) 50 deg C, 6 h

2: 87 percent / TsOH / CH₂Cl₂; methanol / Ambient temperature

3: 84 percent / I₂, Ph₃P, imidazole / CH₂Cl₂ / Ambient temperature

4: 70 percent / DBU / tetrahydrofuran / Ambient temperature

5: 70 percent / m-CPBA / CH₂Cl₂ / 3 h / 0 °C

With 1H-imidazole; 18-crown-6 ether; iodine; potassium hydride; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00014a023