(2R,3R,4S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2,4,5-tris-(tert-butyl-dimethyl-silanyloxy)-pentan-3-ol

Base Information

Chemical Name:(2R,3R,4S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2,4,5-tris-(tert-butyl-dimethyl-silanyloxy)-pentan-3-ol
CAS No.:765942-31-2
Molecular Formula:C₄₄H₇₂O₇Si₃
Molecular Weight:797.308
Hs Code.:

Synonyms:(2R,3R,4S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2,4,5-tris-(tert-butyl-dimethyl-silanyloxy)-pentan-3-ol

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Chemical Property of (2R,3R,4S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2,4,5-tris-(tert-butyl-dimethyl-silanyloxy)-pentan-3-ol

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Technology Process of (2R,3R,4S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2,4,5-tris-(tert-butyl-dimethyl-silanyloxy)-pentan-3-ol

There total 9 articles about (2R,3R,4S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2,4,5-tris-(tert-butyl-dimethyl-silanyloxy)-pentan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.6%

: 765942-30-1
(2S,3S,4R)-3,5-dihydroxy-1,2,4-O-tri-tert-butyldimethylsilyloxypentane

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 765942-31-2
(2R,3R,4S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2,4,5-tris-(tert-butyl-dimethyl-silanyloxy)-pentan-3-ol

Guidance literature:: In pyridine; at 20 ℃; for 6h;
DOI:10.1021/jo049033d

Reference yield:

: 37077-81-9
1,2-isopropylidene-α-D-ribofuranose

: 765942-31-2
(2R,3R,4S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2,4,5-tris-(tert-butyl-dimethyl-silanyloxy)-pentan-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / tetrahydrofuran / 1 h / 20 °C

1.2: 91.5 percent / tetrahydrofuran / 2 h / Heating

2.1: aq. AcOH / 3.5 h / Heating

2.2: 91.8 percent / NaBH₄ / methanol / 20 °C

3.1: 97.6 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

4.1: 92.7 percent / H₂ / Pd(OH)2/C / ethyl acetate / 2585.74 Torr

5.1: 96.6 percent / pyridine / 6 h / 20 °C

With 2,6-dimethylpyridine; hydrogen; sodium hydride; acetic acid; palladium dihydroxide; In tetrahydrofuran; pyridine; dichloromethane; ethyl acetate;
DOI:10.1021/jo049033d

Reference yield:

: 765942-29-8
(2S,3S,4R)-3,5-O-dibenzyloxy-1,2,4-O-tri-tert-butyldimethylsilyloxypentane

: 765942-31-2
(2R,3R,4S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2,4,5-tris-(tert-butyl-dimethyl-silanyloxy)-pentan-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 92.7 percent / H₂ / Pd(OH)2/C / ethyl acetate / 2585.74 Torr

2: 96.6 percent / pyridine / 6 h / 20 °C

With hydrogen; palladium dihydroxide; In pyridine; ethyl acetate;
DOI:10.1021/jo049033d