N⁴-benzyl-3-nitro-6-(4-(trifluoromethoxy)benzyl)-N²-(2,4,4-trimethylpentan-2-yl)pyridine-2,4-diamine

Base Information

• Chemical Name: N⁴-benzyl-3-nitro-6-(4-(trifluoromethoxy)benzyl)-N²-(2,4,4-trimethylpentan-2-yl)pyridine-2,4-diamine
• CAS No.: 1457967-22-4
• Molecular Formula: C₂₈H₃₃F₃N₄O₃
• Molecular Weight: 530.59

Synonyms:N⁴-benzyl-3-nitro-6-(4-(trifluoromethoxy)benzyl)-N²-(2,4,4-trimethylpentan-2-yl)pyridine-2,4-diamine

Chemical Property of N⁴-benzyl-3-nitro-6-(4-(trifluoromethoxy)benzyl)-N²-(2,4,4-trimethylpentan-2-yl)pyridine-2,4-diamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N⁴-benzyl-3-nitro-6-(4-(trifluoromethoxy)benzyl)-N²-(2,4,4-trimethylpentan-2-yl)pyridine-2,4-diamine

There total 6 articles about N⁴-benzyl-3-nitro-6-(4-(trifluoromethoxy)benzyl)-N²-(2,4,4-trimethylpentan-2-yl)pyridine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4,4,5,5-tetramethyl-2-[[4-(trifluoromethoxy)phenyl]methyl]-1,3,2-dioxaborolane (872038-32-9) + N4-benzyl-6-chloro-3-nitro-N2-(2,4,4-trimethylpentan-2-yl)pyridine-2,4-diamine (1457966-69-6) → N4-benzyl-3-nitro-6-(4-(trifluoromethoxy)benzyl)-N2-(2,4,4-trimethylpentan-2-yl)pyridine-2,4-diamine (1457967-22-4)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,4-dioxane; water; at 90 ℃; for 18h; Inert atmosphere; Sealed tube;

DOI:10.1039/c3ob40816g

Reference yield: 70.0%

→ N4-benzyl-3-nitro-6-(4-(trifluoromethoxy)benzyl)-N2-(2,4,4-trimethylpentan-2-yl)pyridine-2,4-diamine (1457967-22-4)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,4-dioxane; water; at 90 ℃; for 18h; Inert atmosphere; Sealed tube;

Reference yield:

2,6-dichloro-[4]pyridylamine (2587-02-2) → N4-benzyl-3-nitro-6-(4-(trifluoromethoxy)benzyl)-N2-(2,4,4-trimethylpentan-2-yl)pyridine-2,4-diamine (1457967-22-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sulfuric acid; nitric acid / 1 h / 0 - 20 °C

2.1: sulfuric acid / 0.5 h / 90 °C

3.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.2: 2 h / 20 °C

4.1: triethylamine / dichloromethane / 48 h / Reflux

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / water; 1,4-dioxane / 18 h / 90 °C / Inert atmosphere; Sealed tube

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sulfuric acid; nitric acid; sodium hydride; caesium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 5.1: |Suzuki Coupling;

DOI:10.1039/c3ob40816g

upstream raw materials:

2,6-dichloro-[4]pyridylamine

2,6-dichloro-N-nitro-4-pyridinamine

4,4,5,5-tetramethyl-2-[[4-(trifluoromethoxy)phenyl]methyl]-1,3,2-dioxaborolane

N⁴-benzyl-6-chloro-3-nitro-N²-(2,4,4-trimethylpentan-2-yl)pyridine-2,4-diamine

Downstream raw materials:

C₂₈H₃₅F₃N₄O

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