diethyl 2-[1-benzyloxy-4-(2-fluorophenyl)-pyrazol-5-yl]-2-tert-butoxycarbonylamino-malonate

Base Information

Chemical Name:diethyl 2-[1-benzyloxy-4-(2-fluorophenyl)-pyrazol-5-yl]-2-tert-butoxycarbonylamino-malonate
CAS No.:439101-41-4
Molecular Formula:C₂₈H₃₂FN₃O₇
Molecular Weight:541.576
Hs Code.:

Synonyms:diethyl 2-[1-benzyloxy-4-(2-fluorophenyl)-pyrazol-5-yl]-2-tert-butoxycarbonylamino-malonate

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Chemical Property of diethyl 2-[1-benzyloxy-4-(2-fluorophenyl)-pyrazol-5-yl]-2-tert-butoxycarbonylamino-malonate

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Technology Process of diethyl 2-[1-benzyloxy-4-(2-fluorophenyl)-pyrazol-5-yl]-2-tert-butoxycarbonylamino-malonate

There total 1 articles about diethyl 2-[1-benzyloxy-4-(2-fluorophenyl)-pyrazol-5-yl]-2-tert-butoxycarbonylamino-malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 350609-62-0
1-benzyloxy-4-(2-fluorophenyl)pyrazole

: 408346-61-2
2-(N-tert-butoxycarbonylimino)malonic acid diethyl ester

: 439101-41-4
diethyl 2-[1-benzyloxy-4-(2-fluorophenyl)-pyrazol-5-yl]-2-tert-butoxycarbonylamino-malonate

Guidance literature:: 1-benzyloxy-4-(2-fluorophenyl)pyrazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.116667h;

2-(N-tert-butoxycarbonylimino)malonic acid diethyl ester; In tetrahydrofuran; hexane; at -78 ℃; for 3h;
DOI:10.1016/S0040-4020(02)00021-2

Reference yield: 99.0%

: 439101-41-4
diethyl 2-[1-benzyloxy-4-(2-fluorophenyl)-pyrazol-5-yl]-2-tert-butoxycarbonylamino-malonate

: 439101-49-2
diethyl 2-tert-butoxycarbonylamino-2-[4-(2-fluorophenyl)-1-hydroxypyrazol-5-yl]-malonate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 0 ℃; for 0.75h;
DOI:10.1016/S0040-4020(02)00021-2

Reference yield:

: 439101-41-4
diethyl 2-[1-benzyloxy-4-(2-fluorophenyl)-pyrazol-5-yl]-2-tert-butoxycarbonylamino-malonate

: 2-tert-butoxycarbonylamino-2-[4-(2-fluoro-phenyl)-2-hydroxy-2H-pyrazol-3-yl]-malonic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / hydrogen / 10 percent palladium on carbon / methanol / 0.75 h / 0 °C

2: 2.5M aq. LiOH / tetrahydrofuran / 12 h / 50 °C

With lithium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4020(02)00021-2