N-[4-(aminosulfonyl)-2-methylphenyl]-2-{4-chloro-2-[hydroxy(3-fluorophenyl)methyl]phenoxy}acetamide

Base Information

Chemical Name:N-[4-(aminosulfonyl)-2-methylphenyl]-2-{4-chloro-2-[hydroxy(3-fluorophenyl)methyl]phenoxy}acetamide
CAS No.:1333119-66-6
Molecular Formula:C₂₂H₂₀ClFN₂O₅S
Molecular Weight:478.929
Hs Code.:

Synonyms:N-[4-(aminosulfonyl)-2-methylphenyl]-2-{4-chloro-2-[hydroxy(3-fluorophenyl)methyl]phenoxy}acetamide

Suppliers and Price of N-[4-(aminosulfonyl)-2-methylphenyl]-2-{4-chloro-2-[hydroxy(3-fluorophenyl)methyl]phenoxy}acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[4-(aminosulfonyl)-2-methylphenyl]-2-{4-chloro-2-[hydroxy(3-fluorophenyl)methyl]phenoxy}acetamide

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Technology Process of N-[4-(aminosulfonyl)-2-methylphenyl]-2-{4-chloro-2-[hydroxy(3-fluorophenyl)methyl]phenoxy}acetamide

There total 2 articles about N-[4-(aminosulfonyl)-2-methylphenyl]-2-{4-chloro-2-[hydroxy(3-fluorophenyl)methyl]phenoxy}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.4%

: 329936-15-4
C₂₂H₁₈ClFN₂O₅S

: 1333119-66-6
N-[4-(aminosulfonyl)-2-methylphenyl]-2-{4-chloro-2-[hydroxy(3-fluorophenyl)methyl]phenoxy}acetamide

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; at 0 ℃; Reflux;
DOI:10.1016/j.bmc.2011.07.003

Reference yield:

: 329944-57-2
N-[4-(aminosulfonyl)-2-methylphenyl]-2-bromoacetamide

: 62433-31-2
5-Chlor-2-hydroxyphenyl-3'-fluorphenyl-keton

: 1333119-66-6
N-[4-(aminosulfonyl)-2-methylphenyl]-2-{4-chloro-2-[hydroxy(3-fluorophenyl)methyl]phenoxy}acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; potassium iodide / acetone / 2 h / 50 °C

2: sodium tetrahydroborate / tetrahydrofuran / 0 °C / Reflux

With sodium tetrahydroborate; potassium carbonate; potassium iodide; In tetrahydrofuran; acetone;
DOI:10.1016/j.bmc.2011.07.003