2-(N,N-diethylaminocarbonyloxymethyl)-4-(4-hydroxy-3,5-dimethoxybenzoyl)-1-(3,4,5-trimethoxybenzoyl)piperazine

Base Information

Chemical Name:2-(N,N-diethylaminocarbonyloxymethyl)-4-(4-hydroxy-3,5-dimethoxybenzoyl)-1-(3,4,5-trimethoxybenzoyl)piperazine
CAS No.:819075-21-3
Molecular Formula:C₂₉H₃₉N₃O₁₀
Molecular Weight:589.643
Hs Code.:

Synonyms:2-(N,N-diethylaminocarbonyloxymethyl)-4-(4-hydroxy-3,5-dimethoxybenzoyl)-1-(3,4,5-trimethoxybenzoyl)piperazine

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Chemical Property of 2-(N,N-diethylaminocarbonyloxymethyl)-4-(4-hydroxy-3,5-dimethoxybenzoyl)-1-(3,4,5-trimethoxybenzoyl)piperazine

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Technology Process of 2-(N,N-diethylaminocarbonyloxymethyl)-4-(4-hydroxy-3,5-dimethoxybenzoyl)-1-(3,4,5-trimethoxybenzoyl)piperazine

There total 4 articles about 2-(N,N-diethylaminocarbonyloxymethyl)-4-(4-hydroxy-3,5-dimethoxybenzoyl)-1-(3,4,5-trimethoxybenzoyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.5%

: 530-57-4
3,5-dimethoxy-4-hydroxybenzoic acid

: 253873-20-0
2-(N,N-diethylaminocarbonyloxymethyl)-1-(3,4,5-trimethoxybenzoyl)piperazine

: 819075-21-3
2-(N,N-diethylaminocarbonyloxymethyl)-4-(4-hydroxy-3,5-dimethoxybenzoyl)-1-(3,4,5-trimethoxybenzoyl)piperazine

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; Heating;
DOI:10.1021/jm040860g

Reference yield:

: 253873-18-6
3-(N,N-diethylaminocarbonyloxymethyl)-1-(triphenylmethyl)piperazine

: 819075-21-3
2-(N,N-diethylaminocarbonyloxymethyl)-4-(4-hydroxy-3,5-dimethoxybenzoyl)-1-(3,4,5-trimethoxybenzoyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / triethylamine / CH₂Cl₂ / 20 °C

2: 93 percent / hydrochloric acid / methanol / 0 - 20 °C

3: 84.5 percent / N,N'-dicyclohexylcarbodiimide; 1-hydroxybenzotriazole / CH₂Cl₂ / Heating

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane;
DOI:10.1016/j.bmc.2006.07.031

Reference yield:

: diethyl-carbamic acid piperazin-2-ylmethyl ester; compound with GENERIC INORGANIC NEUTRAL COMPONENT

: 819075-21-3
2-(N,N-diethylaminocarbonyloxymethyl)-4-(4-hydroxy-3,5-dimethoxybenzoyl)-1-(3,4,5-trimethoxybenzoyl)piperazine

Guidance literature:: Multi-step reaction with 4 steps

1: 99.7 percent / triethylamine / CH₂Cl₂ / 6 h / 0 °C

2: 89 percent / triethylamine / CH₂Cl₂ / 20 °C

3: 93 percent / hydrochloric acid / methanol / 0 - 20 °C

4: 84.5 percent / N,N'-dicyclohexylcarbodiimide; 1-hydroxybenzotriazole / CH₂Cl₂ / Heating

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane;
DOI:10.1016/j.bmc.2006.07.031