4-[1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperidin-4-ylamino]-3-nitrobenzoic acid tert-butyl ester

Base Information

Chemical Name:4-[1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperidin-4-ylamino]-3-nitrobenzoic acid tert-butyl ester
CAS No.:253191-92-3
Molecular Formula:C₂₆H₃₂N₆O₆
Molecular Weight:524.577
Hs Code.:

Synonyms:4-[1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperidin-4-ylamino]-3-nitrobenzoic acid tert-butyl ester

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Chemical Property of 4-[1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperidin-4-ylamino]-3-nitrobenzoic acid tert-butyl ester

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Technology Process of 4-[1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperidin-4-ylamino]-3-nitrobenzoic acid tert-butyl ester

There total 3 articles about 4-[1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperidin-4-ylamino]-3-nitrobenzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 23680-84-4
2-chloro-6,7-dimethoxyquinazolin-4-amine

: 253192-25-5
3-Nitro-4-(piperidin-4-ylamino)benzoic acid tert-butyl ester

: 253191-92-3
4-[1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperidin-4-ylamino]-3-nitrobenzoic acid tert-butyl ester

Guidance literature:: In pentan-1-ol; at 120 ℃; for 12h;
DOI:10.1021/jm9903500

Reference yield:

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 253191-92-3
4-[1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperidin-4-ylamino]-3-nitrobenzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / N,N'-diisopropylethylamine / dimethylformamide / 24 h / 110 °C

2: 59 percent / HCl / dioxane / 12 h / 25 °C

3: 64 percent / pentan-1-ol / 12 h / 120 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; pentan-1-ol; N,N-dimethyl-formamide; 1: Substitution / 2: acidolysis / 3: Substitution;
DOI:10.1021/jm9903500

Reference yield:

: 253192-24-4
4-(4-tert-butoxycarbonyl-2-nitrophenylamino)piperidine-1-carboxylic acid tert-butyl ester

: 253191-92-3
4-[1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperidin-4-ylamino]-3-nitrobenzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / HCl / dioxane / 12 h / 25 °C

2: 64 percent / pentan-1-ol / 12 h / 120 °C

With hydrogenchloride; In 1,4-dioxane; pentan-1-ol; 1: acidolysis / 2: Substitution;
DOI:10.1021/jm9903500