RTI 539

Base Information

Chemical Name:RTI 539
CAS No.:855834-83-2
Molecular Formula:C₁₆H₂₀FNO₂
Molecular Weight:277.339
Hs Code.:

Synonyms:RTI 539

Suppliers and Price of RTI 539

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of RTI 539

Chemical Property:

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Technology Process of RTI 539

There total 4 articles about RTI 539 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 855848-93-0
3α-(3-fluoro-4-methylphenyl)tropane-2β-carboxylic acid methyl ester

: 855834-83-2
RTI 539

Guidance literature:: 3α-(3-fluoro-4-methylphenyl)tropane-2β-carboxylic acid methyl ester; With carbonochloridic acid 1-chloro-ethyl ester; In 1,2-dichloro-ethane; for 12h; Heating;

With methanol; for 4h; Heating;
DOI:10.1021/jm058164j

Reference yield:

: 3α-(3-fluoro-4-methylphenyl)-2β-(3'-methyl-1',2',4'-oxadiazol-5'-yl)tropane

: 855834-83-2
RTI 539

Guidance literature:: Multi-step reaction with 2 steps

1.1: nickel acetate tetrahydrate; NaBH₄ / methanol / 4 h / Heating

2.1: 1-chloroethyl chloroformate / 1,2-dichloro-ethane / 12 h / Heating

2.2: 66 percent / MeOH / 4 h / Heating

With sodium tetrahydroborate; carbonochloridic acid 1-chloro-ethyl ester; nickel diacetate; In methanol; 1,2-dichloro-ethane;
DOI:10.1021/jm058164j

Reference yield:

: 51436-99-8
2-fluoro-4-bromotoluene

: 855834-83-2
RTI 539

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / diethyl ether; hexane / 0.5 h / -78 °C

1.2: 36 percent / diethyl ether; hexane / 4 h / -78 °C

2.1: nickel acetate tetrahydrate; NaBH₄ / methanol / 4 h / Heating

3.1: 1-chloroethyl chloroformate / 1,2-dichloro-ethane / 12 h / Heating

3.2: 66 percent / MeOH / 4 h / Heating

With sodium tetrahydroborate; n-butyllithium; carbonochloridic acid 1-chloro-ethyl ester; nickel diacetate; In methanol; diethyl ether; hexane; 1,2-dichloro-ethane;
DOI:10.1021/jm058164j