4-(3,3-dimethyl-6-(4-morpholinyl)-2,3-dihydro-1H-indol-1-yl)-3-methyl-2-phenylquinoline

Base Information

Chemical Name:4-(3,3-dimethyl-6-(4-morpholinyl)-2,3-dihydro-1H-indol-1-yl)-3-methyl-2-phenylquinoline
CAS No.:1259513-63-7
Molecular Formula:C₃₀H₃₁N₃O
Molecular Weight:449.596
Hs Code.:

Synonyms:4-(3,3-dimethyl-6-(4-morpholinyl)-2,3-dihydro-1H-indol-1-yl)-3-methyl-2-phenylquinoline

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Chemical Property of 4-(3,3-dimethyl-6-(4-morpholinyl)-2,3-dihydro-1H-indol-1-yl)-3-methyl-2-phenylquinoline

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Technology Process of 4-(3,3-dimethyl-6-(4-morpholinyl)-2,3-dihydro-1H-indol-1-yl)-3-methyl-2-phenylquinoline

There total 2 articles about 4-(3,3-dimethyl-6-(4-morpholinyl)-2,3-dihydro-1H-indol-1-yl)-3-methyl-2-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 64495-56-3
4-chloro-3-methyl-2-phenylquinoline

: 1259511-94-8
4-(3,3-dimethylindolin-6-yl)morpholine

: 1259513-63-7
4-(3,3-dimethyl-6-(4-morpholinyl)-2,3-dihydro-1H-indol-1-yl)-3-methyl-2-phenylquinoline

Guidance literature:: 4-(3,3-dimethylindolin-6-yl)morpholine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.333333h; Inert atmosphere;

4-chloro-3-methyl-2-phenylquinoline; In N,N-dimethyl-formamide; mineral oil; at 130 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jm300679u

Reference yield:

: 453562-71-5
1-(6-amino-3,3-dimethyl-2,3-dihydroindol-1-yl)ethanone

: 1259513-63-7
4-(3,3-dimethyl-6-(4-morpholinyl)-2,3-dihydro-1H-indol-1-yl)-3-methyl-2-phenylquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / methanol / 1 h / 150 °C / Inert atmosphere

2.1: hydrogenchloride / acetonitrile; water / 2 h / 95 °C / Inert atmosphere

3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

3.2: 12 h / 130 °C / Inert atmosphere

With hydrogenchloride; sodium hydride; sodium carbonate; In methanol; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1021/jm300679u