{2-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-6-fluorophenyl}methanol

Base Information

Chemical Name:{2-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-6-fluorophenyl}methanol
CAS No.:1198273-68-5
Molecular Formula:C₂₀H₁₄ClFN₂O
Molecular Weight:352.795
Hs Code.:

Synonyms:{2-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-6-fluorophenyl}methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of {2-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-6-fluorophenyl}methanol

Chemical Property:

Purity/Quality:

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Technology Process of {2-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-6-fluorophenyl}methanol

There total 5 articles about {2-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-6-fluorophenyl}methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1198273-69-6
6-[2-(tert-Butyldimethylsilanyloxymethyl)-3-fluorophenyl]-2-(4-chlorophenyl)imidazo[1,2-a]pyridine

: 1198273-68-5
{2-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-6-fluorophenyl}methanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 360575-28-6
2-bromo-6-fluorobenzaldehyde

: 1198273-68-5
{2-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-6-fluorophenyl}methanol

Guidance literature:: Multi-step reaction with 5 steps

1: methanol; sodium tetrahydroborate / 1 h / Cooling with ice

2: 1H-imidazole / tetrahydrofuran / 16 h

3: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

4: sodium hydrogencarbonate / ethanol / 18 h / 80 °C / Inert atmosphere

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With 1H-imidazole; methanol; sodium tetrahydroborate; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 261723-33-5
(2-bromo-6-fluorophenyl)methanol

: 1198273-68-5
{2-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-6-fluorophenyl}methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole / tetrahydrofuran / 16 h

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

3: sodium hydrogencarbonate / ethanol / 18 h / 80 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With 1H-imidazole; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;