1-(2-Difluoromethoxy-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Base Information

Chemical Name:1-(2-Difluoromethoxy-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester
CAS No.:122551-47-7
Molecular Formula:C₁₉H₁₃F₄NO₄
Molecular Weight:395.31
Hs Code.:

Synonyms:1-(2-Difluoromethoxy-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Suppliers and Price of 1-(2-Difluoromethoxy-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(2-Difluoromethoxy-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(2-Difluoromethoxy-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

There total 4 articles about 1-(2-Difluoromethoxy-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 122551-44-4
ethyl α-<<<2-(difluoromethoxy)phenyl>amino>methylene>-2,4,5-trifluoro-β-oxo-benzenepropionate ester

: 122551-47-7
1-(2-Difluoromethoxy-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: With sodium carbonate; In N,N-dimethyl-formamide; 1) room temperature, 30 min; 2) 100 deg C, 30 min;
DOI:10.1002/jps.2600780716

Reference yield:

: 22225-77-0
1-difluoromethoxy-2-nitro-benzene

: 122551-47-7
1-(2-Difluoromethoxy-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / H₂ / Pd/C / ethanol; H₂O / 0.33 h / Ambient temperature

2: 54.3 percent / ethanol / 1 h / Ambient temperature

3: 88 percent / Na₂CO₃ / dimethylformamide / 1) room temperature, 30 min; 2) 100 deg C, 30 min

With hydrogen; sodium carbonate; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1002/jps.2600780716

Reference yield:

: 88-75-5,78813-12-4
2-hydroxynitrobenzene

: 122551-47-7
1-(2-Difluoromethoxy-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / aq. NaOH / tetrahydrofuran / 24 h / Ambient temperature

2: 76 percent / H₂ / Pd/C / ethanol; H₂O / 0.33 h / Ambient temperature

3: 54.3 percent / ethanol / 1 h / Ambient temperature

4: 88 percent / Na₂CO₃ / dimethylformamide / 1) room temperature, 30 min; 2) 100 deg C, 30 min

With sodium hydroxide; hydrogen; sodium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1002/jps.2600780716