(1E,3E)-5-((S)-3,4-dihydro-1-(2-(tert-butyldiphenylsilanyloxy)ethyl)-9-carbobenzyloxy-1H-pyrido[3,4-b]indol-2-yl)penta-1,3-dienyl benzoate

Base Information

• Chemical Name: (1E,3E)-5-((S)-3,4-dihydro-1-(2-(tert-butyldiphenylsilanyloxy)ethyl)-9-carbobenzyloxy-1H-pyrido[3,4-b]indol-2-yl)penta-1,3-dienyl benzoate
• CAS No.: 1011533-76-8
• Molecular Formula: C₄₉H₅₀N₂O₅Si
• Molecular Weight: 775.032
• Mol file: 1011533-76-8.mol

Synonyms:(1E,3E)-5-((S)-3,4-dihydro-1-(2-(tert-butyldiphenylsilanyloxy)ethyl)-9-carbobenzyloxy-1H-pyrido[3,4-b]indol-2-yl)penta-1,3-dienyl benzoate

Chemical Property of (1E,3E)-5-((S)-3,4-dihydro-1-(2-(tert-butyldiphenylsilanyloxy)ethyl)-9-carbobenzyloxy-1H-pyrido[3,4-b]indol-2-yl)penta-1,3-dienyl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1E,3E)-5-((S)-3,4-dihydro-1-(2-(tert-butyldiphenylsilanyloxy)ethyl)-9-carbobenzyloxy-1H-pyrido[3,4-b]indol-2-yl)penta-1,3-dienyl benzoate

There total 1 articles about (1E,3E)-5-((S)-3,4-dihydro-1-(2-(tert-butyldiphenylsilanyloxy)ethyl)-9-carbobenzyloxy-1H-pyrido[3,4-b]indol-2-yl)penta-1,3-dienyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(1E,3E)-5-((S)-3,4-dihydro-1-(2-(tert-butyldiphenylsilanyloxy)ethyl)-1H-pyrido[3,4-b]indol-2(9H)-yl)penta-1,3-dienyl benzoate (1011533-74-6) + benzyl chloroformate (501-53-1,94274-21-2) → (1E,3E)-5-((S)-3,4-dihydro-1-(2-(tert-butyldiphenylsilanyloxy)ethyl)-9-carbobenzyloxy-1H-pyrido[3,4-b]indol-2-yl)penta-1,3-dienyl benzoate (1011533-76-8)

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; at 0 ℃; for 0.666667h;

DOI:10.1021/ol702781q

Reference yield: 85.0%

(1E,3E)-5-((S)-3,4-dihydro-1-(2-(tert-butyldiphenylsilanyloxy)ethyl)-9-carbobenzyloxy-1H-pyrido[3,4-b]indol-2-yl)penta-1,3-dienyl benzoate (1011533-76-8) → (1E,3E)-5-((S)-3,4-dihydro-1-(2-hydroxyethyl)-9-carbobenzyloxy-1H-pyrido[3,4-b]indol-2-yl)penta-1,3-dienyl benzoate (1011533-77-9)

Guidance literature:

With tetrabutyl ammonium fluoride; In 2,2,2-trifluoroethanol; at 0 - 23 ℃; for 1.5h;

DOI:10.1021/ol702781q

upstream raw materials:

(1E,3E)-5-((S)-3,4-dihydro-1-(2-(tert-butyldiphenylsilanyloxy)ethyl)-1H-pyrido[3,4-b]indol-2(9H)-yl)penta-1,3-dienyl benzoate

benzyl chloroformate

Downstream raw materials:

(1E,3E)-5-((S)-3,4-dihydro-1-(2-hydroxyethyl)-9-carbobenzyloxy-1H-pyrido[3,4-b]indol-2-yl)penta-1,3-dienyl benzoate