Technology Process of tert-butyl (2S)-benzenesulfonylamino-3-[3-chloro-4-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionate
There total 8 articles about tert-butyl (2S)-benzenesulfonylamino-3-[3-chloro-4-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
N,N-dimethyl-formamide;
for 13h;
DOI:10.1016/j.bmc.2005.10.061
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 66 percent / dimethylsulfoxide / 72 h / 120 °C
2: Et3N / CH2Cl2 / 1 h
3: NaN3 / dimethylformamide / 5 h / 80 °C
4: 595 mg / H2; AcOH / Pd/C / dioxane / 4 h / 20 °C
5: (i-Pr)2NEt / dimethylformamide / 10 h / 125 °C
6: 109 mg / NaOH / methanol; tetrahydrofuran; H2O / 8 h / 40 °C
7: 85 percent / 1-hydroxybenzotriazole hydrate; N-methylmorpholine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 13 h
With
4-methyl-morpholine; sodium hydroxide; sodium azide; hydrogen; acetic acid; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.10.061
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 66 percent / dimethylsulfoxide / 72 h / 120 °C
2: Et3N / CH2Cl2 / 1 h
3: NaN3 / dimethylformamide / 5 h / 80 °C
4: 595 mg / H2; AcOH / Pd/C / dioxane / 4 h / 20 °C
5: (i-Pr)2NEt / dimethylformamide / 10 h / 125 °C
6: 109 mg / NaOH / methanol; tetrahydrofuran; H2O / 8 h / 40 °C
7: 85 percent / 1-hydroxybenzotriazole hydrate; N-methylmorpholine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 13 h
With
4-methyl-morpholine; sodium hydroxide; sodium azide; hydrogen; acetic acid; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.10.061
