methyl (2S)-2-(4-{[4-(4-chloro-2-methylphenoxy)piperidin-1-yl]methyl}piperidin-1-yl)-3-(4-fluorophenyl)-2-methylpropanoate

Base Information

Chemical Name:methyl (2S)-2-(4-{[4-(4-chloro-2-methylphenoxy)piperidin-1-yl]methyl}piperidin-1-yl)-3-(4-fluorophenyl)-2-methylpropanoate
CAS No.:921204-72-0
Molecular Formula:C₂₉H₃₈ClFN₂O₃
Molecular Weight:517.084
Hs Code.:

Synonyms:methyl (2S)-2-(4-{[4-(4-chloro-2-methylphenoxy)piperidin-1-yl]methyl}piperidin-1-yl)-3-(4-fluorophenyl)-2-methylpropanoate

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Chemical Property of methyl (2S)-2-(4-{[4-(4-chloro-2-methylphenoxy)piperidin-1-yl]methyl}piperidin-1-yl)-3-(4-fluorophenyl)-2-methylpropanoate

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Technology Process of methyl (2S)-2-(4-{[4-(4-chloro-2-methylphenoxy)piperidin-1-yl]methyl}piperidin-1-yl)-3-(4-fluorophenyl)-2-methylpropanoate

There total 2 articles about methyl (2S)-2-(4-{[4-(4-chloro-2-methylphenoxy)piperidin-1-yl]methyl}piperidin-1-yl)-3-(4-fluorophenyl)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl 4-fluoro-α-methyl-L-phenylalaninate

: 921204-94-6
4-{[4-(4-chloro-2-methylphenoxy)piperidin-1-yl]methyl}cyclopentane-1,2-diol

: 921204-72-0
methyl (2S)-2-(4-{[4-(4-chloro-2-methylphenoxy)piperidin-1-yl]methyl}piperidin-1-yl)-3-(4-fluorophenyl)-2-methylpropanoate

Guidance literature:: 4-{[4-(4-chloro-2-methylphenoxy)piperidin-1-yl]methyl}cyclopentane-1,2-diol; With sodium periodate; acetic acid; In water; for 0.5h;

With potassium carbonate; In water;

methyl 4-fluoro-α-methyl-L-phenylalaninate; With sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid; more than 3 stages;

Reference yield:

: methyl 4-fluoro-α-methyl-L-phenylalaninate

: C₁₈H₂₄ClNO₃

: 921204-72-0
methyl (2S)-2-(4-{[4-(4-chloro-2-methylphenoxy)piperidin-1-yl]methyl}piperidin-1-yl)-3-(4-fluorophenyl)-2-methylpropanoate

Guidance literature:: With sodium triacetoxy borohydride; acetic acid; at 20 ℃; for 18h;
DOI:10.1016/j.bmcl.2012.08.103

Reference yield:

: 921204-72-0
methyl (2S)-2-(4-{[4-(4-chloro-2-methylphenoxy)piperidin-1-yl]methyl}piperidin-1-yl)-3-(4-fluorophenyl)-2-methylpropanoate

: 921204-64-0
(2S)-2-(4-{[4-(4-chloro-2-methylphenoxy)piperidin-1-yl]methyl}piperidin-1-yl)-3-(4-fluorophenyl)-2-methylpropanoic acid hydrate

Guidance literature:: methyl (2S)-2-(4-{[4-(4-chloro-2-methylphenoxy)piperidin-1-yl]methyl}piperidin-1-yl)-3-(4-fluorophenyl)-2-methylpropanoate; With hydrogen bromide; In water; at 160 ℃; for 72h;

With lithium hydroxide; water;

With ammonium acetate; In 2-Methylpentane; water; acetonitrile; for 2h;