3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid

Base Information

Chemical Name:3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid
CAS No.:152607-82-4
Molecular Formula:C₂₆H₂₇FO₅
Molecular Weight:438.496
Hs Code.:

Synonyms:3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid

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Chemical Property of 3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid

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Technology Process of 3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid

There total 8 articles about 3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 152608-92-9
3-<2-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>phenyl>propanoic acid

: 152607-82-4
3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; under 760 Torr; Ambient temperature;
DOI:10.1021/jm00022a006

Reference yield: 15.0%

: 152607-82-4
3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid

Guidance literature:

Reference yield:

: 29682-12-0
1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone

: 152607-82-4
3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / K₂CO₃ / dimethylsulfoxide; butan-2-one / 24 h / Heating

2: 69 percent / trifluoroacetic acid, triethylsilane / CCl₄ / 1.5 h / Ambient temperature

3: 73 percent / N-bromosuccinimide / CCl₄ / 6 h / Ambient temperature

4: 84 percent / Pd(PPh₃)4, aq. Na₂CO₃ / ethanol; benzene / 16 h / Heating

5: 1.) NaH / 1.) DMSO, THF, RT, 15 min, 2.) DMSO, THF, RT, 1.5 h

6: 70 percent / aq. NaOH / methanol; tetrahydrofuran / 1 h / Ambient temperature

7: 75 percent / H₂ / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature

With triethylsilane; sodium hydroxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium hydride; sodium carbonate; potassium carbonate; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; dimethyl sulfoxide; ethyl acetate; butanone; benzene;
DOI:10.1021/jm00022a006