4-[1-(phenylsulfonyl)-1H-pyrrol-2-yl]-2, 4-dioxobutanoic acid methyl ester

Base Information

• Chemical Name: 4-[1-(phenylsulfonyl)-1H-pyrrol-2-yl]-2, 4-dioxobutanoic acid methyl ester
• CAS No.: 875553-34-7
• Molecular Formula: C₁₅H₁₃NO₆S
• Molecular Weight: 335.337
• Mol file: 875553-34-7.mol

Synonyms:4-[1-(phenylsulfonyl)-1H-pyrrol-2-yl]-2, 4-dioxobutanoic acid methyl ester

Chemical Property of 4-[1-(phenylsulfonyl)-1H-pyrrol-2-yl]-2, 4-dioxobutanoic acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 4-[1-(phenylsulfonyl)-1H-pyrrol-2-yl]-2, 4-dioxobutanoic acid methyl ester

There total 1 articles about 4-[1-(phenylsulfonyl)-1H-pyrrol-2-yl]-2, 4-dioxobutanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

Dimethyl oxalate (553-90-2) + 1-(1-(phenylsulfonyl)-1H-pyrrol-2-yl)ethan-1-one (86688-88-2) → 4-[1-(phenylsulfonyl)-1H-pyrrol-2-yl]-2, 4-dioxobutanoic acid methyl ester (875553-34-7)

Guidance literature:

1-(1-(phenylsulfonyl)-1H-pyrrol-2-yl)ethan-1-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.583333h;

Dimethyl oxalate; In tetrahydrofuran; at 20 ℃; for 3.66667h;

Reference yield: 71.0%

3-Chloro-6-hydrazinopyridazine (17284-97-8) + 4-[1-(phenylsulfonyl)-1H-pyrrol-2-yl]-2, 4-dioxobutanoic acid methyl ester (875553-34-7) → 1-(6-chloro-3-pyridazinyl)-5-[1-(phenylsulfonyl)-1H-pyrrol-2-yl]-1H-pyrazole-3-carboxylic acid methyl ester (875553-35-8)

Guidance literature:

3-Chloro-6-hydrazinopyridazine; 4-[1-(phenylsulfonyl)-1H-pyrrol-2-yl]-2, 4-dioxobutanoic acid methyl ester; In methanol; for 16.5h; Heating / reflux;

With hydrogenchloride; In methanol; water; for 4.66667h; Heating / reflux;

With sodium hydrogencarbonate; In methanol; water;

upstream raw materials:

Dimethyl oxalate

1-(1-(phenylsulfonyl)-1H-pyrrol-2-yl)ethan-1-one

Downstream raw materials:

1-(6-chloro-3-pyridazinyl)-5-[1-(phenylsulfonyl)-1H-pyrrol-2-yl]-1H-pyrazole-3-carboxylic acid methyl ester