(3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-11-{(1R,2S)-2-[(E)-2-hydroxy-3-methyl-4-(5-trityloxymethyl-pyridin-2-yl)-but-3-enyl]-cyclopropyl}-4,4,6,8-tetramethyl-5-oxo-undecanoic acid

Base Information

Chemical Name:(3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-11-{(1R,2S)-2-[(E)-2-hydroxy-3-methyl-4-(5-trityloxymethyl-pyridin-2-yl)-but-3-enyl]-cyclopropyl}-4,4,6,8-tetramethyl-5-oxo-undecanoic acid
CAS No.:472962-25-7
Molecular Formula:C₆₀H₈₇NO₇Si₂
Molecular Weight:990.524
Hs Code.:

(3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-11-{(1R,2S)-2-[(E)-2-hydroxy-3-methyl-4-(5-trityloxymethyl-pyridin-2-yl)-but-3-enyl]-cyclopropyl}-4,4,6,8-tetramethyl-5-oxo-undecanoic acid

Synonyms:(3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-11-{(1R,2S)-2-[(E)-2-hydroxy-3-methyl-4-(5-trityloxymethyl-pyridin-2-yl)-but-3-enyl]-cyclopropyl}-4,4,6,8-tetramethyl-5-oxo-undecanoic acid

Suppliers and Price of (3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-11-{(1R,2S)-2-[(E)-2-hydroxy-3-methyl-4-(5-trityloxymethyl-pyridin-2-yl)-but-3-enyl]-cyclopropyl}-4,4,6,8-tetramethyl-5-oxo-undecanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-11-{(1R,2S)-2-[(E)-2-hydroxy-3-methyl-4-(5-trityloxymethyl-pyridin-2-yl)-but-3-enyl]-cyclopropyl}-4,4,6,8-tetramethyl-5-oxo-undecanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-11-{(1R,2S)-2-[(E)-2-hydroxy-3-methyl-4-(5-trityloxymethyl-pyridin-2-yl)-but-3-enyl]-cyclopropyl}-4,4,6,8-tetramethyl-5-oxo-undecanoic acid

There total 2 articles about (3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-11-{(1R,2S)-2-[(E)-2-hydroxy-3-methyl-4-(5-trityloxymethyl-pyridin-2-yl)-but-3-enyl]-cyclopropyl}-4,4,6,8-tetramethyl-5-oxo-undecanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 472962-25-7
(3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-11-{(1R,2S)-2-[(E)-2-hydroxy-3-methyl-4-(5-trityloxymethyl-pyridin-2-yl)-but-3-enyl]-cyclopropyl}-4,4,6,8-tetramethyl-5-oxo-undecanoic acid

Guidance literature:

Reference yield:

: (3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-11-{(1R,2S)-2-[(E)-2-hydroxy-3-methyl-4-(5-trityloxymethyl-pyridin-2-yl)-but-3-enyl]-cyclopropyl}-4,4,6,8-tetramethyl-5-oxo-undecanoic acid 2-trimethylsilanyl-ethyl ester

: 472962-25-7
(3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-11-{(1R,2S)-2-[(E)-2-hydroxy-3-methyl-4-(5-trityloxymethyl-pyridin-2-yl)-but-3-enyl]-cyclopropyl}-4,4,6,8-tetramethyl-5-oxo-undecanoic acid

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 25 ℃; for 2h;
DOI:10.1016/S0040-4020(02)00655-5

Reference yield: 33.0%

: 472962-25-7
(3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-11-{(1R,2S)-2-[(E)-2-hydroxy-3-methyl-4-(5-trityloxymethyl-pyridin-2-yl)-but-3-enyl]-cyclopropyl}-4,4,6,8-tetramethyl-5-oxo-undecanoic acid

: (1S,3R,7S,10R,11S,12S,16R)-7,11-Bis-(tert-butyl-dimethyl-silanyloxy)-8,8,10,12-tetramethyl-3-[(E)-1-methyl-2-(5-trityloxymethyl-pyridin-2-yl)-vinyl]-4-oxa-bicyclo[14.1.0]heptadecane-5,9-dione

: 472962-32-6
(1S,3S,7S,10R,11S,12S,16R)-7,11-Bis-(tert-butyl-dimethyl-silanyloxy)-8,8,10,12-tetramethyl-3-[(E)-1-methyl-2-(5-trityloxymethyl-pyridin-2-yl)-vinyl]-4-oxa-bicyclo[14.1.0]heptadecane-5,9-dione

Guidance literature:: (3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-11-{(1R,2S)-2-[(E)-2-hydroxy-3-methyl-4-(5-trityloxymethyl-pyridin-2-yl)-but-3-enyl]-cyclopropyl}-4,4,6,8-tetramethyl-5-oxo-undecanoic acid; With 2,4,6-trichlorobenzoyl chloride; triethylamine; In tetrahydrofuran; at 0 ℃; for 1h;

With dmap; In tetrahydrofuran; toluene; at 75 ℃; for 3h;
DOI:10.1016/S0040-4020(02)00655-5